yohimbine (generic name)
Mederek (brand name)
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CategoryHerbs & Supplements
Aphrodien, Corynanthe johimbi, Corynanthe yohimbi, corynine, johimbi, Pausinystalia johimbe, Pausinystalia yohimbe, quebrachine, Rubiaceae (family), yohimbehe, yohimbehe cortex, yohimbeherinde, yohimbene, yohimbime, yohimbine.
The terms yohimbine, yohimbine hydrochloride, and yohimbe bark extract are related but not interchangeable. Yohimbine is an active chemical (indole alkaloid) found in the bark of the Pausinystalia yohimbe tree. Yohimbine hydrochloride is a standardized form of yohimbine that is available as a prescription drug in the United States and has been shown in human studies to be effective in the treatment of male impotence. Yohimbine hydrochloride has also been used for the treatment of sexual side effects caused by some antidepressants (SSRIs), female hyposexual disorder, as a blood pressure boosting agent in autonomic failure, xerostomia, and as a probe for noradrenergic activity.
EvidenceDISCLAIMER: These uses have been tested in humans or animals. Safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider.
Dry mouth (xerostomia):
Studies report that yohimbine is able to increase saliva in animals and in humans. Based on these few studies, yohimbine has been used for the treatment of dry mouth caused by medications, such as antidepressants. However, yohimbe bark extract may not contain significant amounts of yohimbine and therefore may not have these effects. More research is needed before a strong recommendation can be made.
Erectile dysfunction (male impotence):
Yohimbine hydrochloride is a prescription drug that has been shown in multiple human trials to effectively treat male impotence. Yohimbine may also be a useful treatment option in orgasmic dysfunction. Although yohimbine is present in yohimbe bark extract, levels are variable and often very low. Therefore, although yohimbe bark has been used traditionally to reduce male erectile dysfunction, there is not enough scientific evidence to form a firm conclusion in this area.
Inhibition of platelet aggregation:
Pre-clinical studies report that yohimbine alkaloid, isolated from yohimbe bark, may inhibit platelet aggregation. Research in humans is limited, and more research is necessary in this area.
Libido (women) :
Yohimbine has been proposed to increase female libido (sexual interest). There is only limited poor-quality research in this area, and more study is needed before a strong recommendation can be made.
Nervous system dysfunction (autonomic failure):
It is theorized that yohimbine may improve orthostatic hypotension (lowering of blood pressure with standing) or other symptoms of autonomic nervous system dysfunction. However, yohimbe bark extract may not contain significant amounts of yohimbine, and therefore may not have these proposed effects. More research is needed before a strong recommendation can be made.
Sexual side effects of selective serotonin reuptake inhibitor (SSRI) antidepressants:
Yohimbine hydrochloride, a standardized form of yohimbine that is available as a prescription drug in the United States, has been suggested to treat sexual dysfunction due to SSRI antidepressants. However, research in this area is limited, and more study is needed before a recommendation can be made. In addition, yohimbe bark extract may not contain significant amounts of yohimbine and therefore may not have these proposed effects.
Muscle mass / body mass:
Yohimbine combined with resistance training does not appear to alter body mass, muscle mass, or exercise performance.