ascorbic acid (generic name)

a vitamin - treats Urinary tract infection, Complex regional pain syndrome, Bleeding stomach ulcers caused by aspirin, Vaginitis, Stroke preven...
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Interactions

Interactions with Drugs

Vitamin C may increase adverse effects associated with acetaminophen or aluminum-containing antacids such as aluminum hydroxide (Maalox®, Gaviscon®).

Vitamin C may increase blood levels and adverse effects of aspirin, whereas aspirin may decrease blood levels of vitamin C.

The effects of vitamin C may be decreased by barbiturates including phenobarbital (Luminal®, Donnatal®), pentobarbital (Nembutal®), or secobarbital (Seconal®).

Vitamin C supplementation may decrease levels of the drug fluphenazine in the body.

Concomitant administration of high doses of vitamin C can reduce steady-state indinavir plasma concentrations.

There is limited case report evidence that high dose vitamin C may reduce side effects of levodopa therapy such as nausea or malcoordination.

Nicotine products such as cigarettes, cigars, chewing tobacco, or nicotine patches may decrease the effects of vitamin C.

Oral estrogens may decrease the effects of vitamin C in the body. When taken together, vitamin C may increase blood levels of ethinyl estradiol.

The effects of vitamin C may be decreased by tetracycline antibiotics such as doxycycline (Vibramycin®), minocycline (Minocin®), or tetracycline (Sumycin®).

Vitamin C in high doses appears to interfere with the blood thinning effects of warfarin by lowering prothrombin time (PT), as noted in case reports in the 1970s. Complications have not been reported (such as increased blood clots).

High doses of vitamin C are not recommended in patients with kidney failure. Caution is advised when taking vitamin C and drugs that may damage the kidneys due to an increased risk of kidney failure.

Interactions with Herbs and Dietary Supplements

When taken together, vitamin C may increase the absorption of iron in the gastrointestinal tract, although this effect appears to be variable and may not be clinically significant.

Vitamin C may increase absorption of lutein vitamin supplements.

Large doses of vitamin C may interfere with the absorption and metabolism of vitamin B12.

In theory, large doses of vitamin C may also interact with herbs and supplements with hormonal, antibacterial and blood thinning (anticoagulant) activity.

Caution is advised when taking vitamin C and agents that may damage the kidneys due to an increased risk of kidney failure.

Attribution

This information is based on a systematic review edited and peer-reviewed by contributors to the Natural Standard Research Collaboration (www.naturalstandard.com): Ethan Basch, MD (Memorial Sloan-Kettering Cancer Center); Dawn Costa, BA, BS (Natural Standard Research Collaboration); Jill M. Grimes Serrano, PhD (Natural Standard Research Collaboration); Jenna Hollenstein, MS, RD (Natural Standard Research Collaboration); Shaina Tanguay-Colucci, BS (Natural Standard Research Collaboration); Catherine Ulbricht, PharmD (Massachusetts College of Pharmacy); Christine Ulbricht, BS (University of Massachusetts); Wendy Weissner, BA (Natural Standard Research Collaboration).

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