s-adenosylmethionine (generic name)
a nutraceutical product - treats Depression, Osteoarthritis, Cholestasis, Fibromyalgia, Attention deficit hyperactivity disorder, and Liver dis...
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Interactions with Drugs
SAMe may lower blood sugar levels. Caution is advised when using medications that may also lower blood sugar. Patients taking drugs for diabetes by mouth or insulin should be monitored closely by a qualified healthcare professional, including a pharmacist. Medication adjustments may be necessary.
Use cautiously in patients using tricyclic antidepressant drugs, such as clomipramine. Combination of SAMe and tricyclic antidepressant drugs may increase the likelihood of adverse effects.
Interactions with Herbs and Dietary Supplements
SAMe may lower blood sugar levels. Caution is advised when using herbs or supplements that may also lower blood sugar. Blood glucose levels may require monitoring, and doses may need adjustment.
This information is based on a systematic review of scientific literature, and was peer-reviewed and edited by contributors to the Natural Standard Research Collaboration (www.naturalstandard.com): Ernie-Paul Barrette, MD, FACP (Case Western Reserve University); Ethan Basch, MD, MSc, MPhil (Memorial Sloan-Kettering Cancer Center); Julie Conquer, PhD (RGB Consulting); Catherine Farber, MS (Northeastern University); Paul Hammerness, MD (Harvard Medical School); Charlotte A. Kenreigh, PharmD (MLC Solutions, LTD); Shaina Tanguay-Colucci, BS (Natural Standard Research Collaboration); Catherine Ulbricht, PharmD (Massachusetts General Hospital); Linda Timm Wagner, PharmD (MLC Solutions, LTD); Wendy Weissner, BA (Natural Standard Research Collaboration); Denise Wong, PharmD (Northeastern University).
BibliographyDISCLAIMER: Natural Standard developed the above evidence-based information based on a thorough systematic review of the available scientific articles. For comprehensive information about alternative and complementary therapies on the professional level, go to www.naturalstandard.com. Selected references are listed below.
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Tavoni A, Vitali C, Bombardieri S, et al. Evaluation of S-adenosylmethionine in primary fibromyalgia. A double- blind crossover study. Am J Med 11-20-1987;83(5A):107-110.
Volkmann H, Norregaard J, Jacobsen S, et al. Double-blind, placebo-controlled cross-over study of intravenous S- adenosyl-L-methionine in patients with fibromyalgia. Scand J Rheumatol. 1997;26(3):206-211.