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s-adenosylmethionine (generic name)

a nutraceutical product - treats Depression, Osteoarthritis, Cholestasis, Fibromyalgia, Attention deficit hyperactivity disorder, and Liver dis...
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Interactions with Drugs

SAMe may lower blood sugar levels. Caution is advised when using medications that may also lower blood sugar. Patients taking drugs for diabetes by mouth or insulin should be monitored closely by a qualified healthcare professional, including a pharmacist. Medication adjustments may be necessary.

Use cautiously in patients using tricyclic antidepressant drugs, such as clomipramine. Combination of SAMe and tricyclic antidepressant drugs may increase the likelihood of adverse effects.

Interactions with Herbs and Dietary Supplements

SAMe may lower blood sugar levels. Caution is advised when using herbs or supplements that may also lower blood sugar. Blood glucose levels may require monitoring, and doses may need adjustment.


This information is based on a systematic review of scientific literature, and was peer-reviewed and edited by contributors to the Natural Standard Research Collaboration ( Ernie-Paul Barrette, MD, FACP (Case Western Reserve University); Ethan Basch, MD, MSc, MPhil (Memorial Sloan-Kettering Cancer Center); Julie Conquer, PhD (RGB Consulting); Catherine Farber, MS (Northeastern University); Paul Hammerness, MD (Harvard Medical School); Charlotte A. Kenreigh, PharmD (MLC Solutions, LTD); Shaina Tanguay-Colucci, BS (Natural Standard Research Collaboration); Catherine Ulbricht, PharmD (Massachusetts General Hospital); Linda Timm Wagner, PharmD (MLC Solutions, LTD); Wendy Weissner, BA (Natural Standard Research Collaboration); Denise Wong, PharmD (Northeastern University).


DISCLAIMER: Natural Standard developed the above evidence-based information based on a thorough systematic review of the available scientific articles. For comprehensive information about alternative and complementary therapies on the professional level, go to Selected references are listed below.

Arnold O, Saletu B, Anderer P, et al. Double-blind, placebo-controlled pharmacodynamic studies with a nutraceutical and a pharmaceutical dose of ademetionine (SAMe) in elderly subjects, utilizing EEG mapping and psychometry. Eur.Neuropsychopharmacol. 2005;15(5):533-543.

Binder T, Salaj P, Zima T, et al. Randomized prospective comparative study of ursodeoxycholic acid and S-adenosyl-L-methionine in the treatment of intrahepatic cholestasis of pregnancy. J Perinat Med 2006;34(5):383-91.

Bogarapu S, Bishop JR, Krueger CD, et al. Complementary medicines in pediatric bipolar disorder. Minerva Pediatr 2008 Feb;60(1):103-14.

Bradley JD, Flusser D, Katz BP, et al. A randomized, double blind, placebo controlled trial of intravenous loading with S-adenosylmethionine (SAM) followed by oral SAM therapy in patients with knee osteoarthritis. J Rheumatol. 1994;21(5):905-911.

Burrows RF, Clavisi O, Burrows E. Interventions for treating cholestasis in pregnancy (Cochrane Review). Cochrane Database Syst Rev 2001;4:CD000493.

Mato JM, Camara J, Fernandez de Paz, et al. S-adenosylmethionine in alcoholic liver cirrhosis: a randomized, placebo-controlled, double-blind, multicenter clinical trial. J Hepatol 1999;30(6):1081-1089.

Mato JM, Lu SC. Role of S-adenosyl-L-methionine in liver health and injury. Hepatology 2007 May;45(5):1306-12.

Muscettola G, Galzenati M, Balbi A. SAMe versus placebo: a double blind comparison in major depressive disorders. Advances in Biochemical Psychopharmacology 1982;32:151-156.

Nicastri PL, Diaferia A, Tartagni M, et al. A randomised placebo-controlled trial of ursodeoxycholic acid and S- adenosylmethionine in the treatment of intrahepatic cholestasis of pregnancy. Br J Obstet.Gynaecol. 1998;105(11):1205-1207.

Ribalta J, Reyes H, Gonzalez MC, et al. S-adenosyl-L-methionine in the treatment of patients with intrahepatic cholestasis of pregnancy: a randomized, double-blind, placebo- controlled study with negative results. Hepatology 1991;13(6):1084-1089.

Rambaldi A, Gluud C. S-adenosyl-L-methionine for alcoholic liver diseases. Cochrane Database Syst Rev 2006 Apr 19;(2):CD002235.

Roncaglia N, Locatelli A, Bellini P, et al. A randomized controlled trial of ursodeoxycholic acid and S-adenosyl-L-methionine in the treatment of gestational cholestasis. Am J Obstet Gynecol 2000;182(1 pt 2):S167.

Roncaglia N, Locatelli A, Arreghini A, et al. A randomised controlled trial of ursodeoxycholic acid and S-adenosyl-l-methionine in the treatment of gestational cholestasis. BJOG 2004;111(1):17-21.

Tavoni A, Vitali C, Bombardieri S, et al. Evaluation of S-adenosylmethionine in primary fibromyalgia. A double- blind crossover study. Am J Med 11-20-1987;83(5A):107-110.

Volkmann H, Norregaard J, Jacobsen S, et al. Double-blind, placebo-controlled cross-over study of intravenous S- adenosyl-L-methionine in patients with fibromyalgia. Scand J Rheumatol. 1997;26(3):206-211.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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