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s-adenosylmethionine (generic name)

a nutraceutical product - treats Depression, Osteoarthritis, Cholestasis, Fibromyalgia, Attention deficit hyperactivity disorder, and Liver dis...
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WARNING: DISCLAIMER: The below uses are based on tradition, scientific theories, or limited research. They often have not been thoroughly tested in humans, and safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider. There may be other proposed uses that are not listed below.
Acetaminophen metabolism (hepatic cirrhosis), adjustment disorder, aging, alcoholism, Alzheimer's disease, anxiety, bilirubin and polyphyrin metabolism disorders, bursitis, cirrhosis (primary biliary), dementia, bipolar disorder, drug/toxin induced hepatotoxicity (liver damage), gastritis (hemorrhagic), Gilbert's syndrome, heart disease, hepatitis, high cholesterol, infertility, intrahepatic cholestasis (oral-contraceptive-induced), intrahepatic cholestasis (total parenteral nutrition-induced), ischemic stroke, lead toxicity, male sterility, migraine, multiple sclerosis, pancreatitis, myelopathy (spinal cord injury), Parkinson's disease, post-concussive syndrome, postpartum depression, premenstrual syndrome, premenstrual dysphoric disorder, psychiatric illness, rheumatoid arthritis, seizures, Sjogren's syndrome, systemic sclerosis, tendonitis.


Adults (18 years and older):

Both oral (taken by mouth) and intravenous (injection) preparations of SAMe have been studied in clinical trials with some evidence of benefit for certain conditions. SAMe appears effective for osteoarthritis, and 600-1,200 milligrams has been taken daily in 1-3 divided doses for 10-84 days. Up to 1,600 milligrams has been taken for up to two weeks for the treatment of cholestasis. For depression, 800-1,600 milligrams daily was the most commonly used dosage range in clinical studies, for up to six weeks. For fibromyalgia, 400 milligrams twice daily has been used. For intrahepatic cholestasis of pregnancy, 500 milligrams given twice daily has been used. For general liver disease, 600-1,200 milligrams daily has also been used.

As an injection into the muscle, the most common dose for SAMe is 200-400 milligrams for 2-4 weeks. Both S-adenosyl-L-methionine 1,4-butanedisulphonate stable salt and disulfate-p-toluenesulfonate stable salt have been studied as injections. 500mg SAMe twice daily has also been delivered in a slow running infusion for twelve days followed by oral administration of 500mg twice daily. Injections should only be given under the supervision of a qualified healthcare professional, including a pharmacist.

Children (younger than 18 years):

There is no proven safe or effective dose for SAMe in children.


DISCLAIMER: Many complementary techniques are practiced by healthcare professionals with formal training, in accordance with the standards of national organizations. However, this is not universally the case, and adverse effects are possible. Due to limited research, in some cases only limited safety information is available.


Avoid in individuals with a known allergy or hypersensitivity to S-adenosyl-L-methionine. Flushing, erythema (reddening of the skin), palpitation, dizziness, and nausea (symptoms of an anaphylactic reaction) have been reported.

Side Effects and Warnings

SAMe has been well tolerated in the majority of clinical trials conducted. The most common adverse effects reported are gastrointestinal in nature with nausea being the most frequently reported. Skin rashes have also been reported. Anxiety and hypomania have been reported mainly in trials that have included patients with bipolar disorder. The use of SAMe has not been adequately studied in the pediatric and elderly population, in pregnancy other than the third trimester, or during breastfeeding.

When given as an injection, diluted SAMe has caused superficial phlebitis (inflammation of a vein) and tachycardia (increased heart rate), increased perspiration, transient pain at the injection site, arm soreness, flushing, erythema (reddening of the skin), palpitation, dizziness, nausea, pruritus (itching), urticaria ("hives"), and epigastric pain.

SAMe may lower blood sugar levels. Caution is advised in patients with diabetes or hypoglycemia, and in those taking drugs, herbs, or supplements that affect blood sugar. Serum glucose levels may need to be monitored by a qualified healthcare professional, including a pharmacist, and medication adjustments may be necessary.

When taken by mouth or by injection, SAMe may cause a hot sensation and itchiness of the ear, nausea, vomiting, dry mouth, heartburn, blood in the stool, anorexia, mild diarrhea, stomachaches, slight constipation, increased thirst, increased salivation, urinary frequency, intolerable bowel symptoms, gas, and decreased appetite. Anxiety, insomnia, hypomania, hostility, insomnia, elevated mood, psychoactivation, headache, suicidal ideation, hyperactivity, a reduced need for sleep, and bursts of energy have also been reported.

Pregnancy and Breastfeeding

SAMe crosses the placenta. SAMe is not recommended in the first trimester or during breastfeeding due to a lack of available scientific evidence. However, SAMe has been used in the third trimester for the treatment of intrahepatic cholestasis with no reported adverse effects in the pregnant women or their newborn babies. A single study of SAMe included women in second trimester with no adverse effects noted. Use cautiously in women in their third trimester of pregnancy; SAMe should only be used in pregnancy if the benefits clearly outweigh the risks.

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