Coriolus (generic name)

treats Leukemia, Non-small cell lung cancer, Nasopharyngeal carcinoma, Esophageal cancer, Liver cancer, Colorectal cancer, Breast cancer, Gastr...
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Tradition

WARNING: DISCLAIMER: The below uses are based on tradition, scientific theories, or limited research. They often have not been thoroughly tested in humans, and safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider. There may be other proposed uses that are not listed below.

Dosing

Adults (over 18 years old)

Safety and efficacy has not been proven for any dose. When taken by mouth, 3 grams of PSK has been used daily or every other day, either alone or with conventional therapy. 1 gram, three times daily of PSK for one month, has been used for the treatment of a tumor. PSK has also been administered at a dose of 2-3 grams/meter2 daily in three divided doses for one month.

Children (under 18 years old)

There is not enough evidence available to recommend the use of PSK in children.

Safety

DISCLAIMER: Many complementary techniques are practiced by healthcare professionals with formal training, in accordance with the standards of national organizations. However, this is not universally the case, and adverse effects are possible. Due to limited research, in some cases only limited safety information is available.

Allergies

Avoid in individuals with a known allergy/hypersensitivity to PSK, Coriolus versicolor, or any of its constituents.

Side Effects and Warnings

PSK generally seems to have a low incidence of mild and tolerable side effects. In one report, three cases of toxicity were noted, and PSK was discontinued. PSK has been associated with side effects of gastrointestinal upset and darkening of the fingernails, but these effects have been limited and general safety has been demonstrated with daily oral doses for extended periods. Darkening of the fingernails and coughing have been reported during the administration of the powder drug.

Low blood cell counts including leukopenia, thrombocytopenia, and albuminuria (protein in the urine) were observed in two clinical trials. It should be noted that patients also received chemotherapy in addition to PSK in these trials, which may have contributed.

Use cautiously in patients with coronary artery disease due to antiangiogenic properties (inhibition of new blood vessel growth) in the heart.

Pregnancy and Breastfeeding

Not recommended due to lack of sufficient data.

Interactions

Interactions with Drugs

Liver function impairment and toxicity has been reported. Caution is advised when taking PSK with other agents that are broken down by the liver due to increased risk of side effects.

Antiangiogenic properties (inhibition new blood vessel growth) have been proposed. In theory, there could be an additive effect when PSK is taken in conjugation with other known antiangiogenic agents, such as leflunomide.

Thrombocytopenia (low blood platelet count) has been reported. Theoretically, this could increase the risk of bleeding. Leukopenia and albuminuria were also observed in two clinical trials. It should be noted that patients also received chemotherapy in addition to PSK in these trials. These effects may be attributed to either PSK or chemotherapy.

Numerous animal and human studies have demonstrated that PSK may improve survival time in patients with lung cancer, gastric cancer, stomach cancer, colon cancer, and leukemia when used in conjunction with chemotherapy. This may be a positive interaction, although additional study is needed to confirm this finding.

PSK in immunochemotherapy has been used in combination with hormone therapy to treat pancreatic cancer; therefore, additive effects are possible.

Interactions with Herbs and Dietary Supplements

Liver function impairment and toxicity has been reported. Caution is advised when taking PSK with other agents that are broken down by the liver due to increased risk of side effects.

Antiangiogenic properties (inhibition of new blood vessel growth) have been proposed. In theory, there could be an additive effect when PSK is taken in conjugation with other known antiangiogenic herbs and supplements such as shark cartilage, horse chestnut, feverfew, and bilberry.

Thrombocytopenia (low blood platelet count) has been reported. Theoretically, this could increase the risk of bleeding. Leukopenia and albuminuria were also observed in two clinical trials. It should be noted that patients also received chemotherapy in addition to PSK in these trials. These effects may be attributed to either PSK or chemotherapy.

PSK in immunochemotherapy has been used in combination with hormone therapy to treat pancreatic cancer; therefore, additive effects are possible.

Theoretically, PSK may have a synergistic effect with other immunotherapeutic herbs and supplements. Numerous animal and human studies have demonstrated PSK improves survival time in patients with lung cancer, gastric cancer, stomach cancer, colon cancer, and leukemia when used in conjunction with chemotherapy.

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