Polypodium vulgare (generic name)

treats Psoriasis, Dementia, Atopic dermatitis, Vitiligo, and Skin damage caused by the sun
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DISCLAIMER: Natural Standard developed the above evidence-based information based on a thorough systematic review of the available scientific articles. For comprehensive information about alternative and complementary therapies on the professional level, go to www.naturalstandard.com. Selected references are listed below.

Alcaraz MV, Pathak MA, Rius F, et al. An extract of Polypodium leucotomos appears to minimize certain photoaging changes in a hairless albino mouse animal model. A pilot study. Photodermatol Photoimmunol Photomed 1999 Jun-Aug;15(3-4):120-6.

Alonso-Lebrero JL, Dominguez-Jimenez C, Tejedor R, et al. Photoprotective properties of a hydrophilic extract of the fern Polypodium leucotomos on human skin cells. J Photochem Photobiol B 2003 Apr;70(1):31-7.

Alvarez XA, Franco-Maside A, Zas R, et al. Anapsos reverses interleukin-1 beta overexpression and behavioral deficits in nbM-lesioned rats. Methods Find Exp Clin Pharmacol 1997 Jun;19(5):299-309.

Bernd A, Ramirez-Bosca A, Huber H, et al. In vitro studies on the immunomodulating effects of polypodium leucotomos extract on human leukocyte fractions. Arzneimittelforschung 1995 Aug;45(8):901-4.

Dea-Ayuela M, Rodero M, Rodriguez-Bueno R, et al. Modulation by Anapsos (Polypodium leucotomos extract) of the antibody responses against the nematode parasite Trichinella spiralis. Phytother Res 1999 Nov;13(7):566-70.

Fernandez-Novoa L, Alvarez XA, Sempere JM, et al. Effects of anapsos on the activity of the enzyme Cu-Zn-superoxide dismutase in an animal model of neuronal degeneration. Methods Find Exp Clin Pharmacol 1997 Mar;19(2):99-106.

Gomes AJ, Lunardi CN, Gonzalez S, et al. The antioxidant action of Polypodium leucotomos extract and kojic acid: reactions with reactive oxygen species. Braz J Med Biol Res 2001 Nov;34(11):1487-94.

Gonzalez S, Alcaraz MV, Cuevas J, et al. An extract of the fern Polypodium leucotomos (Difur) modulates Th1/Th2 cytokines balance in vitro and appears to exhibit anti-angiogenic activities in vivo: pathogenic relationships and therapeutic implications. Anticancer Res 2000 May-Jun;20(3A):1567-75.

Gonzalez S, Pathak MA, Cuevas J, et al. Topical or oral administration with an extract of Polypodium leucotomos prevents acute sunburn and psoralen-induced phototoxic reactions as well as depletion of Langerhans cells in human skin. Photodermatol Photoimmunol Photomed 1997 Feb-Apr;13(1-2):50-60.

Gonzalez S, Pathak MA. Inhibition of ultraviolet-induced formation of reactive oxygen species, lipid peroxidation, erythema and skin photosensitization by polypodium leucotomos. Photodermatol Photoimmunol Photomed 1996 Apr;12(2):45-56.

Martinez-Fernandez AR, Nogal-Ruiz JJ, Lopez-Aban J, et al. Vaccination of mice and sheep with Fh12 FABP from Fasciola hepatica using the new adjuvant/immunomodulator system ADAD. Vet Parasitol 2004 Dec 15;126(3):287-98.

Middelkamp-Hup MA, Bos JD, Rius-Diaz F, et al. Treatment of vitiligo vulgaris with narrow-band UVB and oral Polypodium leucotomos extract: a randomized double-blind placebo-controlled study. J Eur Acad Dermatol Venereol 2007 Aug;21(7):942-50.

Middelkamp-Hup MA, Pathak MA, Parrado C, et al. Oral Polypodium leucotomos extract decreases ultraviolet-induced damage of human skin. J Am Acad Dermatol 2004 Dec;51(6):910-8.

Middelkamp-Hup MA, Pathak MA, Parrado C, et al. Orally administered Polypodium leucotomos extract decreases psoralen-UVA-induced phototoxicity, pigmentation, and damage of human skin. J Am Acad Dermatol 2004 Jan;50(1):41-9.

Navarro-Blasco FJ, Sempere JM. Modification of the inflammatory activity of psoriatic arthritis in patients treated with extract of Polipodium leucotomos (Anapsos) Br J Rheumatol 1998 Aug;37(8):912.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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