Polypodium (generic name)
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SafetyDISCLAIMER: Many complementary techniques are practiced by healthcare professionals with formal training, in accordance with the standards of national organizations. However, this is not universally the case, and adverse effects are possible. Due to limited research, in some cases only limited safety information is available.
People with allergies to ferns (family Polypodiaceae) should avoid polypodium.
Side Effects and Warnings
Isolated reports of itching or stomach upset are published. Studies of a different fern species, Polypodium vulgare, report sedation, changes in heart function in animals, low blood pressure, and rapid heart rate. Avoid driving and use of heavy machinery when taking Polypodium leucotomos extract due to theoretical sedative effects. People with heart disease or those being treated for heart disorders or high blood pressure should use caution.
Pregnancy and Breastfeeding
The use of polypodium during pregnancy or breastfeeding is not recommended because there is little information about its safety.
Interactions with Drugs
Polypodium may increase the amount of drowsiness caused by some drugs. Examples include benzodiazepines such as lorazepam (Ativan®) or diazepam (Valium®), barbiturates such as phenobarbital, narcotics such as codeine, some antidepressants, and alcohol. Caution is advised while driving or operating machinery.
Most testing has been done with a related fern species, Polypodium vulgare. Animal studies show that this related plant can affect the function of the heart and lower blood pressure. In theory, the use of Polypodium leucotomos extract with medications that affect heart function or lower blood pressure may cause the effects of these drugs to increase. Use caution if combining polypodium with heart medications such as beta-blockers, calcium channel blockers, or digoxin.
Interactions with Herbs and Dietary Supplements
In theory, polypodium may increase the amount of drowsiness caused by some herbs or supplements.
In studies of a related fern species, Polypodium vulgare, animals treated with the herb developed low blood pressure and changes in heart function. In theory, the use of Polypodium leucotomos extract with herbs or supplements that lower blood pressure may cause the blood pressure to fall too low.
For the same reason, be cautious if using Polypodium leucotomos extract with herbs or supplements that have possible cardiac glycoside ingredients that can affect the function of the heart. Notably, bufalin/chan suis is a Chinese herbal formula that has been reported as toxic or fatal when taken with cardiac glycosides.
This information is based on a professional level monograph edited and peer-reviewed by contributors to the Natural Standard Research Collaboration (www.naturalstandard.com): Ethan Basch, MD (Natural Standard Research Collaboration); Samuel Basch, MD (Mt. Sinai Medical Center, NY); Heather Boon, B.Sc.Phm, PhD (University of Toronto); Dawn Costa, BA, BS (Natural Standard Research Collaboration); Paul Hammerness, MD (Harvard Medical School); Sadaf Hashmi, MD, MPH (Johns Hopkins School of Hygiene and Public Health); Shaina Tanguay-Colucci, BS (Natural Standard Research Collaboration); Catherine Ulbricht, PharmD (Massachusetts General Hospital); Wendy Weissner, BA (Natural Standard Research Collaboration); Jen Woods, BS (Natural Standard Research Collaboration).