Perilla frutescens (generic name)

treats Asthma, Allergies, and Aphthous stomatitis
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DISCLAIMER: Natural Standard developed the above evidence-based information based on a thorough systematic review of the available scientific articles. For comprehensive information about alternative and complementary therapies on the professional level, go to www.naturalstandard.com. Selected references are listed below.

Baba S, Osakabe N, Natsume M, et al. Absorption, metabolism, degradation and urinary excretion of rosmarinic acid after intake of Perilla frutescens extract in humans. Eur J Nutr 2005;44(1):1-9.

Banno N, Akihisa T, Tokuda H, et al. Triterpene acids from the leaves of Perilla frutescens and their anti-inflammatory and antitumor-promoting effects. Biosci.Biotechnol.Biochem 2004;68(1):85-90.

Gulcin I, Berashvili D, Gepdiremen A. Antiradical and antioxidant activity of total anthocyanins from Perilla pankinensis decne. J Ethnopharmacol 10-3-2005;101(1-3):287-293.

Hamazaki K, Itomura M, Hamazaki T, et al. Effects of cooking plant oils on recurrent aphthous stomatitis: a randomized, placebo-controlled, double-blind trial. Nutrition 2006;22(5):534-538.

Kawai K, Matsuno K, Kasai H. Detection of 4-oxo-2-hexenal, a novel mutagenic product of lipid peroxidation, in human diet and cooking vapor. Mutat.Res 2-28-2006;603(2):186-192.

Kim DS, Kim HR, Woo ER, et al. Inhibitory effects of rosmarinic acid on adriamycin-induced apoptosis in H9c2 cardiac muscle cells by inhibiting reactive oxygen species and the activations of c-Jun N-terminal kinase and extracellular signal-regulated kinase. Biochem Pharmacol 10-1-2005;70(7):1066-1078.

Kim HK, Choi H. Stimulation of acyl-CoA oxidase by alpha-linolenic acid-rich perilla oil lowers plasma triacylglycerol level in rats. Life Sci 8-5-2005;77(12):1293-1306.

Kim JH, Jin YR, Park BS, et al. Luteolin prevents PDGF-BB-induced proliferation of vascular smooth muscle cells by inhibition of PDGF beta-receptor phosphorylation. Biochem Pharmacol 6-15-2005;69(12):1715-1721.

Kim JS, Lee HJ, Lee MH, et al. Luteolin inhibits LPS-stimulated inducible nitric oxide synthase expression in BV-2 microglial cells. Planta Med 2006;72(1):65-68.

Ko WC, Shih CM, Leu IJ, et al. Mechanisms of relaxant action of luteolin in isolated guinea pig trachea. Planta Med 2005;71(5):406-411.

Osakabe N, Yasuda A, Natsume M, Yoshikawa T. Rosmarinic acid inhibits epidermal inflammatory responses: anticarcinogenic effect of Perilla frutescens extract in the murine two-stage skin model. Carcinogenesis 2004;25(4):549-557.

Peng Y, Ye J, Kong J. Determination of phenolic compounds in Perilla frutescens L. by capillary electrophoresis with electrochemical detection. J Agric.Food Chem 10-19-2005;53(21):8141-8147.

Qiao S, Li W, Tsubouchi R, et al. Rosmarinic acid inhibits the formation of reactive oxygen and nitrogen species in RAW264.7 macrophages. Free Radic.Res 2005;39(9):995-1003.

Sanbongi C, Takano H, Osakabe N, et al. Rosmarinic acid in perilla extract inhibits allergic inflammation induced by mite allergen, in a mouse model. Clin Exp Allergy 2004;34(6):971-977.

Takagi S, Goto H, Shimada Y, et al. Vasodilative effect of perillaldehyde on isolated rat aorta. Phytomedicine 2005;12(5):333-337.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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