Avoid in individuals with a known allergy or hypersensitivity to pantethine or any component of the formulation.
Pantethine is generally well tolerated. It may cause mild gastrointestinal side effects such as nausea, heartburn, or diarrhea. There is some evidence that pantethine can decrease platelet aggregation, which may increase the risk of bleeding.
Pantethine is not recommended in pregnant or breastfeeding women due to a lack of available scientific evidence.
Theoretically, pantethine may increase the risk of bleeding when taken with drugs that increase the risk of bleeding. Some examples include aspirin, anticoagulants ("blood thinners") such as warfarin (Coumadin®) or heparin, anti-platelet drugs such as clopidogrel (Plavix®), and non-steroidal anti-inflammatory drugs (NSAIDS) such as ibuprofen (Motrin®, Advil®) or naproxen (Naprosyn®, Aleve®).
Taking probucol or cysteamine may cause additive lipid-lowering effects. Caution is advised.
In theory, pantethine may increase the risk of bleeding when taken with herbs and supplements that are believed to increase the risk of bleeding. Multiple cases of bleeding have been reported with the use of Ginkgo biloba, and fewer cases with garlic and saw palmetto. Numerous other agents may theoretically increase the risk of bleeding, although this has not been proven in most cases.
Use of pantethine with other lipid lowering agents, such as red yeast, may produce additive lipid-modulating effects. Caution is advised.
This information is based on a systematic review of scientific literature, and was peer-reviewed and edited by contributors to the Natural Standard Research Collaboration (www.naturalstandard.com): Erica Seamon, PharmD (Nova Southeastern University); Kris Swinney, PharmD (Massachusetts College of Pharmacy); Isabell Syelsky, PharmD (Northeastern University); Brian Szczechowski, PharmD (Massachusetts College of Pharmacy); Shaina Tanguay-Colucci, BS (Natural Standard Research Collaboration); Chris Tonelli, MA (Emmanuel College); Catherine Ulbricht, PharmD (Massachusetts General Hospital); Wendy Weissner, BA (Natural Standard Research Collaboration); Jen Woods, BS (Northeastern University).
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Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.