lactobacillus acidophilus (generic name)
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Interactions with Drugs
Some experts believe that Lactobacillus acidophilus taken by mouth should be used two to three hours after antibiotic doses, to prevent killing the Lactobacillus acidophilus. It has also been suggested that lactobacilli are damaged by alcohol and should not be taken at the same time. Scientific research is limited in these areas.
In theory, Lactobacillus acidophilus taken by mouth might not survive the acidic environment of the stomach. Some experts have suggested that antacids should be taken 30 to 60 minutes before taking lactobacilli. However, this has not been well studied in humans.
In theory, Lactobacillus acidophilus may prolong the effects of some drugs, including birth control pills, the contraceptive vaginal ring, or benzodiazepines such as diazepam (Valium®). Based on laboratory experiments, Lactobacillus acidophilus may reduce the effectiveness of sulfasalazine (Azulfidine®), a drug used for inflammatory bowel disease.
Interactions with Herbs and Dietary Supplements
Fructo-oligosaccharides (FOS, also called "prebiotics") are non-digestible sugar chains that are nutrients for lactobacilli. Some experts believe that FOS, taken by mouth, may help the growth of lactobacilli. Natural food sources of FOS include banana, Jerusalem artichoke, onion, asparagus, and garlic.
Lactobacillus casei, Saccharomyces boulardi, or other probiotics may add to the effects of Lactobacillus acidophilus.
This information is based on a professional level monograph edited and peer-reviewed by contributors to the Natural Standard Research Collaboration (www.naturalstandard.com): Ethan Basch, MD, MPhil, MSc (Memorial Sloan-Kettering Cancer Center); Dawn Costa, BA, BS (Natural Standard Research Collaboration); Ron Dixon, MD (Massachusetts General Hospital); Jenna Hollenstein, MS, RD (Natural Standard Research Collaboration); Carolyn Williams Orlando, MA (American Botanical Council); David Sollars, MAc, HMC (Merrimack College); Shaina Tanguay-Colucci, BS (Natural Standard Research Collaboration); Catherine Ulbricht, PharmD (Massachusetts General Hospital); Mamta Vora, PharmD (Northeastern University); Lisa Wendt, PharmD (Albany College of Pharmacy); Wendy Weissner, BA (Natural Standard Research Collaboration).
BibliographyDISCLAIMER: Natural Standard developed the above evidence-based information based on a thorough systematic review of the available scientific articles. For comprehensive information about alternative and complementary therapies on the professional level, go to www.naturalstandard.com. Selected references are listed below.
Arvola T, Laiho K, Torkkeli S, et al. Prophylactic Lactobacillus GG reduces antibiotic-associated diarrhea in children with respiratory infections: a randomized study. Pediatrics 1999;104(5):e64.
Delia A, Morgante G, Rago G, et al. Effectiveness of oral administration of Lactobacillus paracasei subsp. Paracasei F19 in association with vaginal suppositories of Lactobacillus acidofilus in the treatment of vaginosis and in the prevention of recurrent vaginitis. Minerva Ginecol 2006 Jun;58(3):227-31.
dios Pozo-Olano J, Warram JH, Jr., Gomez RG, et al. Effect of a lactobacilli preparation on traveler's diarrhea. A randomized, double blind clinical trial. Gastroenterology 1978;74(5 Pt 1):829-830.
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Gotteland M, Poliak L, Cruchet S, et al. Effect of regular ingestion of Saccharomyces boulardii plus inulin or Lactobacillus acidophilus LB in children colonized by Helicobacter pylori. Acta Paediatr 2005 Dec;94(12):1747-51.
Hilton E, Isenberg HD, Alperstein P, et al. Ingestion of yogurt containing Lactobacillus acidophilus as prophylaxis for candidal vaginitis. Ann Intern Med 1992;116(5):353-357.
Ishida Y, Nakamura F, Kanzato H, et al. Clinical effects of Lactobacillus acidophilus strain L-92 on perennial allergic rhinitis: a double-blind, placebo-controlled study. J Dairy Sci 2005;88(2):527-533.
Kliegman RM, Willoughby RE. Prevention of necrotizing enterocolitis with probiotics. Pediatrics 2005;115(1):171-172.
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Salazar-Lindo E, Figueroa-Quintanilla D, et al.. Effectiveness and safety of Lactobacillus LB in the treatment of mild acute diarrhea in children. J Pediatr Gastroenterol Nutr 2007 May;44(5):571-6.
Saltzman JR, Russell RM, Golner B, et al. A randomized trial of Lactobacillus acidophilus BG2FO4 to treat lactose intolerance. Am J Clin Nutr 1999;69(1):140-146.
Sazawal S, Hiremath G, Dhingra U, et al. Efficacy of probiotics in prevention of acute diarrhoea: a meta-analysis of masked, randomised, placebo-controlled trials. Lancet Infect Dis 2006 Jun;6(6):374-82.
Taylor AL, Dunstan JA, Prescott SL. Probiotic supplementation for the first 6 months of life fails to reduce the risk of atopic dermatitis and increases the risk of allergen sensitization in high-risk children: a randomized controlled trial. J Allergy Clin Immunol 2007 Jan;119(1):184-91.
Vivatvakin B, Kowitdamrong E. Randomized control trial of live Lactobacillus acidophilus plus Bifidobacterium infantis in treatment of infantile acute watery diarrhea. J Med Assoc Thai 2006 Sep;89 Suppl 3:S126-33.
Xiao SD, Zhang de Z, Lu H, et al. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Adv Ther 2003;20(5):253-260.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.