There is no proven effective dose for gotu kola in adults. For chronic venous insufficiency, varicose veins, or venous hypertension, various dosing regimens have been studied, including 60-120 milligrams daily Centellase® (TTFCA); 30 milligrams twice daily Centellase®; 30 milligrams three times daily TTFCA; 60mg twice daily TTFCA; 60 milligrams TTFCA three times daily. Preliminary studies suggest a dose-dependent response, with better results using 60 milligrams three times daily TTFCA. TECA (titrated extract from Centella asiatica) has also been studied, at a dose of 60-120 milligrams daily. For diabetic microangiopathy, 60 milligrams twice daily of TTFCA (total triterpenic fraction of Centella asiatica) has been studied. Combination products such as CognoBlend® have been studied for liver cirrhosis and cognitive enhancement.
There is no proven effective dose for gotu kola in children.
Avoid in individuals with a known allergy or hypersensitivity to gotu kola or any of its constituents, including asiaticoside, asiatic acid, or madecassic acid. There are numerous reports of allergic contact dermatitis after topical gotu kola use. Allergic contact dermatitis has been reported after the use of topical Blasteostimulina® cream, containing Centella asiatic extract, and after the application of topical Madecassol® ointment.
Studies suggest that gotu kola has few side effects when taken by mouth. Reported symptoms include stomach upset and nausea. In animal research, large doses of gotu kola cause drowsiness, increase cholesterol levels, and raise blood sugar levels. Individuals with diabetes or high cholesterol should avoid gotu kola. Use caution if driving or operating heavy machinery while taking gotu kola as it may cause drowsiness. Asiaticoside, an ingredient of gotu kola, may have weak cancer-causing effects when applied to the skin. There is also a report of night eating syndrome associated with gotu kola.
Gotu kola is not related to the kola nut (Cola nitida, Cola acuminata). Gotu kola is not a stimulant and does not contain caffeine.
In animal studies, gotu kola reduces the ability of a female to become pregnant, but it is not known if this effect occurs in humans. Gotu kola is not recommended during pregnancy or breast-feeding because there is little safety and efficacy information available.