eyebright (generic name)

an herbal product - treats Anti-inflammatory, Conjunctivitis, and Hepatoprotection
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Interactions with Drugs

Eyebright may interfere with the way the body processes certain drugs using the liver's "cytochrome P450" enzyme system. As a result, the levels of these drugs may be altered in the blood, and may cause increased effects or potentially serious adverse reactions. Patients using any medications should check the package insert, and speak with a qualified healthcare professional, including a pharmacist, about possible interactions.

Eyebright may lower blood sugar levels. Caution is advised when using medications that may also lower blood sugar. Patients taking drugs for diabetes by mouth or insulin should be monitored closely by a qualified healthcare professional, including a pharmacist. Medication adjustments may be necessary.

Interactions with Herbs & Dietary Supplements

Eyebright may interfere with the way the body processes certain herbs or supplements using the liver's "cytochrome P450" enzyme system. As a result, the levels of other herbs or supplements may become too high in the blood. It may also alter the effects that other herbs or supplements possibly have on the P450 system.

Theoretically, eyebright may lower blood sugar levels. Caution is advised when using herbs or supplements that may also lower blood sugar. Blood glucose levels may require monitoring, and doses may need adjustment.


This information is based on a systematic review of scientific literature, and was peer-reviewed and edited by contributors to the Natural Standard Research Collaboration (www.naturalstandard.com): Ethan Basch, MD (Memorial Sloan-Kettering Cancer Center); Ivo Foppa, MD, ScD (Harvard University); Paul Hammerness, MD (Harvard Medical School); Mary McGarry, RPh (University of Kansas); George Papaliodis, MD (Massachusetts Eye and Ear Infirmary); Shaina Tanguay-Colucci, BS (Natural Standard Research Collaboration); Catherine Ulbricht, PharmD (Massachusetts General Hospital); Mamta Vora, PharmD (Northeastern University); Wendy Weissner, BA (Natural Standard Research Collaboration).


DISCLAIMER: Natural Standard developed the above evidence-based information based on a thorough systematic review of the available scientific articles. For comprehensive information about alternative and complementary therapies on the professional level, go to www.naturalstandard.com. Selected references are listed below.

Bartholomaeus A, Ahokas J. Inhibtion of P-450 by aucubin: is the biological activity of aucubin due to its glutaraldehyde-like aglycone? Toxicol Lett 1995;80(1-3):75-83.

Bermejo BP, Diaz Lanza AM, Silvan Sen AM, et al. Effects of some iridoids from plant origin on arachidonic acid metabolism in cellular systems. Planta Med 2000;66(4):324-328.

Chang I, Yamaura Y. Aucubin: a new antidote for poisonous amanita mushrooms. Phytother Res 1993;7:53-56.

Chang I. Antiviral activity of Aucubin against Hepatitis B virus replication. Phytother Res 1997;11(3):189-192.

Chang IM. Liver-protective activities of aucubin derived from traditional oriental medicine. Res Commun Mol Pathol Pharmacol 1998;102(2):189-204.

Ersoz T, Berkman MZ, Tasdemir D, et al. An iridoid glucoside from Euphrasia pectinata. J Nat Prod 2000;63(10):1449-1450.

Hattori M, Kawata Y, Inoue K, et al. Transformation of aucubin to new pyridine monoterpene alkaloids, aucubinines A and B, by human intestinal bacteria. Phytother Res 1990;4(2):66-70.

Lee DH, Cho IG, Park MS, et al. Studies on the possible mechanisms of protective activity against alpha- amanitin poisoning by aucubin. Arch Pharm Res 2001;24(1):55-63.

Mokkapatti R. An experimental double-blind study to evaluate the use of Euphrasia in preventing conjunctivitis. Brit Homoeopath J 1992;1(81):22-24.

Porchezhian E, Ansari SH, Shreedharan NK. Antihyperglycemic activity of Euphrasia officinale leaves. Fitoterapia 2000;71(5):522-526.

Recio MC, Giner RM, Manez S, et al. Structural considerations on the iridoids as anti-inflammatory agents. Planta Med 1994;60(3):232-234.

Salama O, Sticher O. Iridoid glucosides from Euphrasia rostkoviana. Part 4. Glycosides from Euphrasia species. Planta Med 1983;47:90-94.

Stoss M, Michels C, Peter E, et al. Prospective cohort trial of Euphrasia single-dose eye drops in conjunctivitis. J Altern Complement Med 2000;6(6):499-508.

Suh NJ, Shim CK, Lee MH, et al. Pharmacokinetic study of an iridoid glucoside: aucubin. Pharm Res 1991;8(8):1059-1063.

Ulubelen A, Topcu G, Eris C, et al. Terpenoids from Salvia sclarea. Phytochemistry 1994;36(4):971-974.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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