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Cordyceps (generic name)

treats Anti-aging, Hyperlipidemia, Hepatitis B, Asthma, Exercise performance enhancement, Liver disease, Renal failure, Bronchitis, Chemoprotec...
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Alternate Title

Cordyceps sinensis

Category

Herbs & Supplements

Synonyms

Aweto, caoor, caterpillar fungus, Chinese caterpillar fungus, chongcao, cordycepin, Cordyceps cicadae, Cordyceps militaris, Cordyceps nipponica, Cordyceps ophioglossoides, Cordyceps pseudomilitaris, Cordyceps sinensis, Cordyceps sinensis (Berk) Succ., Cordyceps sinensis mycelium, Cordyceps spp., Cordyceps tuberbulata, Cs4, CS-4, deer fungus parasite, dong chong xia cao, dong chong zia cao, dong zhong chang cao, fungus, hsia ts'ao tung ch'uung, jinshuibao, mummio, semitake, shilajit, Sphaeria sinensis, summer grass winter worm, summer-plant winter-worm, tochukaso, vegetable caterpillar, yarsha gumba, yertsa gonbu ze-e cordyceps.

Background

Cordyceps sinensis, the Cordyceps species most widely used as a dietary supplement, naturally grows on the back of the larvae of a caterpillar from the moth Hepialus armoricanus Oberthur found mainly in China, Nepal, and Tibet. The mycelium invades the caterpillar and eventually replaces the host tissue. The stroma (fungal fruit body) grows out of the top of the caterpillar. The remaining structures of the caterpillar along with the fungus are dried and sold as the dietary supplement cordyceps.

Commonly known as "dong chong xia cao" (summer-plant, winter-worm) in Chinese, cordyceps has been used as a tonic food in China and Tibet and has been used as a food supplement and tonic beverage among the rich because of its short supply due to over harvesting. It is also an ingredient in soups and other foods used traditionally in Chinese medicine for thousands of years helping debilitated patients recover from illness.

Cordyceps is used therapeutically for asthma, bronchitis, chemoprotection, exercise performance, hepatitis B, hepatic cirrhosis, hyperlipidemia (high cholesterol), as an immunosuppressive agent, and in chronic renal failure.

The fungus became popular in 1993 when two female Chinese athletes, who admitted using cordyceps supplements, beat the world records in the track and field competition at the Stuttgart World Championships for the 1,500-, 3,000-, and 10,000-meter runs. The women were drug tested for any banned substances such as steroids and were negative. Their coach attributed the performance to the cordyceps supplementation.

Evidence

DISCLAIMER: These uses have been tested in humans or animals. Safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider.

Hepatitis B: Cordyceps may stimulate the immune system and improve serum gamma globulin levels in hepatitis B patients. Currently, there is insufficient evidence to recommend for or against the use of cordyceps for chronic hepatitis B. However, the results are promising. Additional study of cordyceps and current hepatitis treatments is needed.
Grade: B

Hyperlipidemia (high cholesterol): Cordyceps may lower total cholesterol and triglyceride levels, although these changes may not be permanent or long lasting. Longer studies with follow up are needed to determine the long-term effects of cordyceps on hyperlipidemia.
Grade: B

Anti-aging: Cordyceps may improve various symptoms related to aging. However, higher quality studies testing specific symptoms of aging are needed before the effects of cordyceps can be described. Currently, there is insufficient evidence to recommend for or against the use of cordyceps for anti-aging.
Grade: C

Asthma: Cordyceps may reduce some asthma symptoms. Additional studies are needed to make a firm recommendation.
Grade: C

Bronchitis: There is insufficient evidence from controlled clinical trials to recommend for or against the use of cordyceps for bronchitis. Most studies using cordyceps have found improved symptoms with cordyceps more than the control drugs. Although results are promising, more studies should be performed before a firm recommendation can be made.
Grade: C

Chemoprotective: There is insufficient evidence to recommend for or against the use of cordyceps as a chemoprotective agent in aminoglycoside toxicity. However, the results are promising.
Grade: C

Exercise performance enhancement: In 1993, two female Chinese athletes, who admitted using cordyceps supplements, beat the world records in the track and field competition at the Stuttgart World Championships for the 1,500-, 3,000-, and 10,000-meter runs. However, there is insufficient evidence from conflicting controlled clinical trials to recommend for or against the use of cordyceps for improving exercise performance. More studies are needed in this area.
Grade: C

Immunosuppression: Two studies using combination herbal treatments that included cordyceps indicate that these combinations suppressed the immune system in kidney transplant and lupus nephritis patients. However, as these treatments used combination products, the effect of cordyceps cannot be defined. More studies with cordyceps as a monotherapy are needed.
Grade: C

Liver disease (hepatic cirrhosis): In traditional Chinese medicine, cordyceps has been used to support and improve liver function. In two studies using herbal combinations that included cordyceps, liver function improved liver and immune function. However, as these studies used combination treatments, the effect of cordyceps alone is unknown.
Grade: C

Renal failure (chronic): In traditional Chinese medicine, cordyceps is used to strengthen kidney function. Two studies indicate that cordyceps may improve renal function in patients with chronic renal failure. More studies are needed to confirm these findings.
Grade: C

Sexual dysfunction: There is not enough available scientific evidence in this area.
Grade: C

Tradition

WARNING: DISCLAIMER: The below uses are based on tradition, scientific theories, or limited research. They often have not been thoroughly tested in humans, and safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider. There may be other proposed uses that are not listed below.
Addiction (opiates), Alzheimer's disease, anemia, anti-inflammatory, antioxidant, arrhythmia (irregular heartbeat), atherosclerosis (hardening of the arteries), bone marrow production, cancer, cardiovascular disease, cough, diabetes, fatigue, fertility, hematopoiesis (formation of blood cells), hemorrhage, hypertension (high blood pressure), longevity, lower backache, memory, menstruation irregularities, mucilage, muscle weakness, nephritis (inflammation of kidneys), neurodegeneration, night sweats, radiation protection, respiratory disease, senility (weakness), systemic lupus erythematosus (SLE), tinnitus, tonic, tranquilizer, tuberculosis, urinary incontinence (nocturia).

Dosing

Adults (18 years and older)

Typical doses of cordyceps are 3-9 grams daily of fermented cordyceps (eg. Cs-4 extract, CordyMax®), which have been given for up to 4-8 weeks. These doses have been used for antiaging, chronic renal failure, hepatitis, and as a chemoprotective or performance enhancer. Lower doses of 999 milligrams taken in three 333-milligram capsules have been studied for hyperlipidemia (high cholesterol).

Children (younger than 18 years)

There is no proven safe or effective dose for cordyceps in children, and use is not recommended.

Safety

DISCLAIMER: Many complementary techniques are practiced by healthcare professionals with formal training, in accordance with the standards of national organizations. However, this is not universally the case, and adverse effects are possible. Due to limited research, in some cases only limited safety information is available.

Allergies

Avoid in individuals with a known allergy or hypersensitivity to cordyceps, mold, or fungi.

Side Effects and Warnings

Minimal side effects have been reported with the use of cordyceps in humans. Cordyceps is likely safe when used in patients with asthma, bronchitis, hepatitis B, hepatic cirrhosis, hyperlipidemia (high cholesterol), immunosuppression, and chronic renal (kidney) failure. It is also likely safe when used as a chemoprotective agent or an exercise performance enhancer, although more study is needed to confirm these findings.

Cordyceps may cause dry mouth, nausea, loss of appetite, diarrhea, or dizziness. Due to the increasing popularity of Cordyceps sinesis, some supplements have been adulterated; some manufacturers substitute other species of cordyceps. The safety of these supplements is not known.

When taken by mouth, cordyceps (jin shiubao capsules) may cause tightness in the chest, wheezing or palpitations. The symptoms may be alleviated after administration of an antihistamine. Skin rashes have also been observed.

Although not well studied in humans, cordyceps's polysaccharides may increase corticosteroid production. Cordyceps may also increase 17beta-estradiol and stimulate progesterone production. It may also inhibit platelet aggregation, and increase the risk of bleeding.

Use cautiously in patients with prostate conditions or in individuals taking immunosuppressive medications, hormonal replacement therapy or birth control. Avoid in patients with myelogenous-type cancers based on reports of cordyceps causing proliferation of progenitor red blood cells.

Pregnancy and Breastfeeding

Cordyceps is not recommended in pregnant or breastfeeding women due to lack of available scientific evidence. Cordyceps may be possibly unsafe in pregnant women, as it may affect steroid hormone levels.

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