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ubidecarenone (generic name)

an herbal product - treats Age-related macular degeneration, Lipid lowering, Parkinson's disease, Exercise performance, Alzheimer's disease, Ti...
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Interactions with Drugs

In theory and based on a human case report, CoQ10 may reduce the effectiveness of warfarin (Coumadin®) and may limit or prevent effective anticoagulation (blood "thinning"). CoQ10 may reduce blood pressure and may add to the effects of other blood pressure-lowering drugs. In theory, CoQ10 may affect thyroid hormone levels and alter the effects of thyroid drugs such as levothyroxine (Synthroid®), although this has not been proven in humans. CoQ10 may also interact with antiretroviral or antiviral drugs.

Based on theory and human research, a number of drugs may deplete natural levels of CoQ10 in the body. It has not been shown that there are benefits of CoQ10 supplements in people using these agents. Examples include: diabetes drugs, tricyclic antidepressants, antipsychotics, beta-blockers, HMG-CoA reductase inhibitors ("statins"), Alzheimer's drugs, heart drugs, cancer drugs, immune system-altering drugs, and diuretic drugs ("water pills").

Interactions with Herbs and Dietary Supplements

CoQ10 may reduce blood pressure and may result in additive effects when taken with other herbs or supplements that also lower blood pressure. Diuretic herbs, such as licorice and horsetail, may also decrease blood pressure and therefore interact with CoQ10. CoQ10 may also interact with herbs and supplements with antiviral effects. In theory, CoQ10 may affect thyroid hormone levels and alter the effects of herbs or supplements that alter the thyroid.

Although not well studied in humans, it is possible that some herbs or supplements used to lower cholesterol or alter blood sugar levels may also decrease the level of CoQ10 in the body.

Red rice yeast may reduce CoQ10 blood levels. CoQ10 may add to the effects or side effects of L-carnitine. CoQ10 may also interact with vitamin A, C, or E. It may also theoretically reduce the effectiveness of warfarin or other blood-thinning agents, such as garlic (Allium sativum), Ginkgo biloba, or saw palmetto (Serenoa repens).

Herbs or supplements used for Alzheimer's disease, heart disorders, diabetes, cancer, viral conditions and immune system-altering may interact with CoQ10.


This patient information is based on a professional level monograph edited and peer-reviewed by contributors to the Natural Standard Research Collaboration ( Ethan Basch, MD (Memorial Sloan-Kettering Cancer Center); Julie Conquer, PharmD (RGB Consulting); Dawn Costa, BA, BS (Natural Standard Research Collaboration); Nicole Giese, MS (Natural Standard Research Collaboration); Paul Hammerness, MD (Massachusetts General Hospital); David Kiefer MD (Bastyr University, University of Arizona, University of Washington); Carolyn Williams Orlando, PhD (American Botanical Council); David Sollars, MAc, HMC (New England School of Acupuncture); Shaina Tanguay-Colucci, BS (Natural Standard Research Collaboration); Catherine Ulbricht, PharmD (Massachusetts General Hospital); Minney Varghese, BS (Northeastern University); Mamta Vora, PharmD (Northeastern University); Wendy Weissner, BA (Natural Standard Research Collaboration); Denise Wong, PharmD (Northeastern University); Jen Woods, BS (Natural Standard Research Collaboration).

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