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cat's claw extract (generic name)

an herbal product - treats Anti-inflammatory, Immune stimulant, Knee pain from osteoarthritis, Allergies, and Cancer
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This information is based on a professional level monograph edited and peer-reviewed by contributors to the Natural Standard Research Collaboration ( Nicole Giese, MS (Natural Standard Research Collaboration); Erica Seamon, PharmD (Nova Southeastern University); Shaina Tanguay-Colucci, BS (Natural Standard Research Collaboration); Catherine Ulbricht, PharmD (Massachusetts General Hospital); Wendy Weissner, BA (Natural Standard Research Collaboration); Shannon Welch, PharmD (Northeastern University).


DISCLAIMER: Natural Standard developed the above evidence-based information based on a thorough systematic review of the available scientific articles. For comprehensive information about alternative and complementary therapies on the professional level, go to Selected references are listed below.

Aguilar JL, Rojas P, Marcelo A, et al. Anti-inflammatory activity of two different extracts of Uncaria tomentosa (Rubiaceae). J Ethnopharmacol 2002;81(2):271-276.

Akesson C, Lindgren H, Pero RW, et al. An extract of Uncaria tomentosa inhibiting cell division and NF-kappa B activity without inducing cell death. Int.Immunopharmacol. 2003;3(13-14):1889-1900.

Allen-Hall L, Cano P, Arnason JT, et al. Treatment of THP-1 cells with Uncaria tomentosa extracts differentially regulates the expression if IL-1beta and TNF-alpha. J Ethnopharmacol 1-19-2007;109(2):312-317.

Ccahuana-Vasquez RA, Santos SS, Koga-Ito CY, et al. Antimicrobial activity of Uncaria tomentosa against oral human pathogens. Braz.Oral Res 2007;21(1):46-50.

Cheng AC, Jian CB, Huang YT, et al. Induction of apoptosis by Uncaria tomentosa through reactive oxygen species production, cytochrome c release, and caspases activation in human leukemia cells. Food Chem Toxicol 2007;45(11):2206-2218.

Garcia Prado E, Garcia Gimenez MD, De la Puerta V, et al. Antiproliferative effects of mitraphylline, a pentacyclic oxindole alkaloid of Uncaria tomentosa on human glioma and neuroblastoma cell lines. Phytomedicine 2007;14(4):280-284.

Hardin SR. Cat's claw: an Amazonian vine decreases inflammation in osteoarthritis. Complement Ther Clin Pract. 2007 Feb;13(1):25-8.

Kitajima M, Hashimoto K, Yokoya M, et al. Two new nor-triterpene glycosides from peruvian "Una de Gato" (Uncaria tomentosa). J Nat.Prod. 2003;66(2):320-323.

Lee J, Son D, Lee P, et al. Alkaloid fraction of Uncaria rhynchophylla protects against N-methyl-D-aspartate-induced apoptosis in rat hippocampal slices. Neurosci.Lett. 9-4-2003;348(1):51-55.

Lee J, Son D, Lee P, et al. Protective effect of methanol extract of Uncaria rhynchophylla against excitotoxicity induced by N-methyl-D-aspartate in rat hippocampus. J Pharmacol Sci. 2003;92(1):70-73.

Moreno SR, Silva AL, Dire G, et al. Effect of oral ingestion of an extract of the herb Uncaria tomentosa on the biodistribution of sodium pertechnetate in rats. Braz.J Med Biol Res 2007;40(1):77-80.

Mur E, Hartig F, Eibl G, et al. Randomized double blind trial of an extract from the pentacyclic alkaloid-chemotype of uncaria tomentosa for the treatment of rheumatoid arthritis. J Rheumatol 2002;29(4):678-681.

Piscoya J, Rodriguez Z, Bustamante SA, et al. Efficacy and safety of freeze-dried cat's claw in osteoarthritis of the knee: mechanisms of action of the species Uncaria guianensis. Inflamm.Res 2001;50(9):442-448.

Setty AR, Sigal LH. Herbal medications commonly used in the practice of rheumatology: mechanisms of action, efficacy, and side effects. Semin.Arthritis Rheum 2005;34(6):773-784.

Valerio LG Jr, Gonzales GF. Toxicological aspects of the South American herbs cat's claw (Uncaria tomentosa) and Maca (Lepidium meyenii): a critical synopsis. Toxicol.Rev 2005;24(1):11-35.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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