Bupleurum (generic name)

treats Fever, Hepatitis, Brain damage, Thrombocytopenic purpura, and Hepatocellular carcinoma
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This information is based on a systematic review of scientific literature, and was peer-reviewed and edited by contributors to the Natural Standard Research Collaboration (www.naturalstandard.com): Ethan Basch, MD (Memorial Sloan-Kettering Cancer Center); Ivo Foppa, MD, ScD (University of South Carolina); Nicole Giese, MS (Natural Standard Research Collaboration); Michael Goble, BS, PharmD (Massachusetts College of Pharmacy); Sadaf Hashmi, MD, MPH (Harvard School of Public Health); Andy Joseph, PharmD (Massachusetts College of Pharmacy); Benjamin Kligler, MD, MPH (Albert Einstein College of Medicine); Michelle Mele, PharmD (Northeastern University); David Sollars MAc, HMC (First Health of Andover); Shaina Tanguay-Colucci, BS (Natural Standard Research Collaboration); Catherine Ulbricht, PharmD, (Massachusetts General Hospital); Minney Varghese, BS (Northeastern University); Mamta Vora, PharmD (Northeastern University); Wendy Weissner, BA (Natural Standard Research Collaboration).


DISCLAIMER: Natural Standard developed the above evidence-based information based on a thorough systematic review of the available scientific articles. For comprehensive information about alternative and complementary therapies on the professional level, go to www.naturalstandard.com. Selected references are listed below.

Aiba T, Takahashi T, Suzuki K, et al. Liver injury induced by a Japanese herbal medicine, sairei-to (TJ-114, Bupleurum and Hoelen Combination, Chai-Ling-Tang) R1. J Gastroenterol Hepatol 2007;22(5):762-763.

Chen YL, Lin SZ, Chang J, et al. In vitro and in vivo studies of a novel potential anticancer agent of isochaihulactone on human lung cancer A549 cells. Biochem Pharmacol 7-28-2006;72(3):308-319.

Cheng BJ, Moritomo A, Yamasaki Y, et al. Preventive effect of traditional herbal formulae against experimental hypercholesterolemia in rats with special reference to blood lipoprotein cholesterol levels. J Ethnopharmacol. 2004;94(2-3):275-278.

Chiang LC, Ng LT, Liu LT, et al. Cytotoxicity and anti-hepatitis B virus activities of saikosaponins from Bupleurum species. Planta Med. 2003;69(8):705-709.

Chou CC, Pan SL, Teng CM, et al. Pharmacological evaluation of several major ingredients of Chinese herbal medicines in human hepatoma Hep3B cells. Eur.J Pharm.Sci. 2003;19(5):403-412.

Duan Y, Zhao X, Xu X, et al. Treatment of primary thrombocytopenic purpura by modified minor decoction of bupleurum. J Tradit.Chin Med. 1995;15(2):96-98.

Estevez-Braun A, Estevez-Reyes R, Moujir LM, et al. Antibiotic activity and absolute configuation of 8S-heptadeca-2(Z),9(Z)-diene-4,6-diyne-1,8-diol from Bupleurum salicifolium. J Nat Prod. 1994;57(8):1178-1182.

Fernandez-Ocana AM, Gomez-Rodriguez MV, Velasco-Negueruela A, et al. In vivo antifungal activity of the essential oil of Bupleurum gibraltarium against Plasmopara halstedii in sunflower. J Agric.Food Chem 10-20-2004;52(21):6414-6417.

Hirayama C, Okumura M, Tanikawa K, et al. A multicenter randomized controlled clinical trial of Shosaiko-to in chronic active hepatitis. Gastroenterol Jpn 1989;24(6):715-719.

Kakumu S, Yoshioka K, Wakita T, et al. Effects of TJ-9 Sho-saiko-to (kampo medicine) on interferon gamma and antibody production specific for hepatitis B virus antigen in patients with type B chronic hepatitis. Int J Immunopharmacol 1991;13(2-3):141-146.

Ikegami F, Sumino M, Fujii Y, et al. Pharmacology and toxicology of Bupleurum root-containing Kampo medicines in clinical use. Hum.Exp Toxicol 2006;25(8):481-494.

Oka H, Yamamoto S, Kuroki T, et al. Prospective study of chemoprevention of hepatocellular carcinoma with Sho-saiko-to (TJ-9). Cancer 9-1-1995;76(5):743-749.

Tajiri H, Kozaiwa K, Ozaki Y, et al. Effect of sho-saiko-to(xiao-chai-hu-tang) on HBeAg clearance in children with chronic hepatitis B virus infection and with sustained liver disease. Am J Chin Med 1991;19(2):121-129.

Xie Y, Lu W, Cao S, et al. Preparation of bupleurum nasal spray and evaluation on its safety and efficacy. Chem Pharm Bull.(Tokyo) 2006;54(1):48-53.

Zhang S, Cheng Z, Huang B, et al. [The effect of he jie decoction on the TCRV beta 7 of chronic hepatitis B patients]. Zhong.Yao Cai. 2002;25(6):451-453.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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