Boron (generic name)

treats Hormone regulation, Bodybuilding aid, Osteoarthritis, Psoriasis, Vaginitis, Menopausal symptoms, Osteoporosis, and Improving cognitive f...
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Interactions with Drugs

Magnesium may interfere with the effects of boron in the body. Sources of magnesium may include antacids containing magnesium oxide or magnesium sulfate (milk of magnesia, Maalox®).

In theory, use of boron with estrogen-active drugs such as birth control pills or hormone replacement therapy may result in increased estrogen effects. Use of boron with testosterone-active drugs such as Testoderm® may result in increased testosterone effects.

Supplemental boron may decrease insulin levels in the blood. It may also alter thyroid hormone levels.

Alzheimer's drugs, analgesics (pain relievers), androgens, anti-inflammatories, antilipemics (cholesterol-lowering), antineoplastic agents, antiviral agents, arthritis agents, dopamine agonists, dopamine antagonists, drugs that damage the liver, osteoporosis agents, and drugs eliminated by the kidney may interact with boron.

Interactions with Herbs and Dietary Supplements

Boron supplementation may result in increased calcium levels in the blood and may add to the effects of calcium or vitamin D supplementation. Boron may interact with herbs or supplements that have effects similar to antacids.

Supplemental boron may decrease phosphorous levels in the blood.

In theory, use of boron with estrogen-active herbs or supplements may result in increased estrogen effects.

Supplemental boron may decrease insulin levels in the blood. It may also alter thyroid hormone levels.

Alzheimer's agents, analgesics (pain relievers), androgens, anti-inflammatoriess, antilipemics (cholesterol-lowering), antineoplastics, antivirals, arthritis agents, dopamine agonists, dopamine antagonists, herbs and supplements that damage the liver, osteoporosis agents, phytoestrogens, and herbs and supplements cleared by the kidneys may interact with boron.


This information is based on a professional level monograph edited and peer-reviewed by contributors to the Natural Standard Research Collaboration ( Ethan Basch, MD (Memorial Sloan-Kettering Cancer Center); Dawn Costa, BA, BS (Natural Standard Research Collaboration); Ron Dixon, MD (Harvard Medical School); Ivo Foppa, MD, ScD (Harvard University); Nicole Giese, MS (Natural Standard Research Collaboration); Dana Hackman, BS (Northeastern University); Paul Hammerness, MD (Massachusetts General Hospital); Sadaf Hashmi, MD, MPH (Johns Hopkins School of Hygiene and Public Health); Michelle Miranda, PharmD (University of Rhode Island); Michael Smith, MRPharmS., ND (Canadian College of Naturopathic Medicine); Erica Seamon, PharmD (Natural Standard Research Collaboration); David Sollars, MAc, HMC (New England School of Acupuncture); Shaina Tanguay-Colucci, BS (Natural Standard Research Collaboration); Catherine Ulbricht, PharmD, MBA[c] (Massachusetts General Hospital); Mamta Vora, PharmD (Northeastern University); Wendy Weissner, BA (Natural Standard Research Collaboration); Meng Yeng, PharmD (ACS-Consultec).


DISCLAIMER: Natural Standard developed the above evidence-based information based on a thorough systematic review of the available scientific articles. For comprehensive information about alternative and complementary therapies on the professional level, go to Selected references are listed below.

Benevolenskaia LI, Toroptsova NV, Nikitinskaia OA, et al. [Vitrum osteomag in prevention of osteoporosis in postmenopausal women: results of the comparative open multicenter trial] Ter Arkh. 2004;76(11):88-93.

Biquet I, Collette J, Dauphin JF, et al. Prevention of postmenopausal bone loss by administration of boron. Osteoporos Int 1996;6 Suppl 1:249.

Devarian TA, Volpe SL. The physiological effects of dietary boron. Crit Rev Food Sci Nutr. 2003;43(2):219-231.

Guaschino S, De Seta F, Sartore A, et al. Efficacy of maintenance therapy with topical boric acid in comparison with oral itraconazole in the treatment of recurrent vulvovaginal candidiasis. Am J Obstet Gynecol 2001;184(4):598-602.

Hunt CD, Herbel JL, Nielsen FH. Metabolic responses of postmenopausal women to supplemental dietary boron and aluminum during usual and low magnesium intake: boron, calcium, and magnesium absorption and retention and blood mineral concentrations. Am J Clin Nutr 1997;65(3):803-813.

Murmu N, Ghosh P, Gomes A, et al. Antineoplastic effect of new boron compounds against leukemic cell lines and cells from leukemic patients. J Exp.Clin.Cancer Res 2002;21(3):351-356.

Nielsen FH, Penland JG. Boron supplementation of peri-menopausal women affects boron metabolism and indices associated with macromineral metabolism, hormonal status and immune function. J Trace Elements Experimental Med 1999;12(3):251-261.

Nielsen FH, Hunt CD, Mullen LM, et al. Effect of dietary boron on mineral, estrogen, and testosterone metabolism in postmenopausal women. FASEB J 1987;1(5):394-397.

Nzietchueng RM, Dousset B, Franck P, et al. Mechanisms implicated in the effects of boron on wound healing. J Trace Elem Med Biol 2002;16(4):239-244.

Penland JG. Dietary boron, brain function, and cognitive performance. Environ Health Perspect 1994;102 Suppl 7:65-72.

Travers RL, Rennie GC, Newnham RE. Boron and arthritis: the results of a double-blind pilot study. J Nutritional Med 1990;1:127-132.

Usuda K, Kono K, Yoshida Y. Serum boron concentration from inhabitants of an urban area in Japan. Reference value and interval for the health screening of boron exposure. Biol Trace Elem Res 1997;56(2):167-178.

Van Slyke KK, Michel VP, Rein MF. The boric acid powder treatment of vulvovaginal candidiasis. J Am Coll.Health Assoc 1981;30(3):107-109.

Van Slyke KK, Michel VP, Rein MF. Treatment of vulvovaginal candidiasis with boric acid powder. Am J Obstet Gynecol. 9-15-1981;141(2):145-148.

Volpe SL, Taper LJ, Meacham S. The relationship between boron and magnesium status and bone mineral density in the human: a review. Magnes Res 1993;6(3):291-296.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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