blue cohosh (generic name)
an herbal product -
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This patient information is based on a systematic review of scientific literature edited and peer-reviewed by contributors to the Natural Standard Research Collaboration (www.naturalstandard.com): James Ceurvels, PharmD (Northeastern University); Jessica Clubb, PharmD (Northeastern University); Molly Davis, PharmD (University of Rhode Island); Nicole Giese, MS (Natural Standard Research Collaboration); Juliann Goodfriend, PharmD (Northeastern University); Shaina Tanguay-Colucci, BS (Natural Standard Research Collaboration); Wendy Weissner, BA (Natural Standard Research Collaboration).
BibliographyDISCLAIMER: Natural Standard developed the above evidence-based information based on a thorough systematic review of the available scientific articles. For comprehensive information about alternative and complementary therapies on the professional level, go to www.naturalstandard.com. Selected references are listed below.
Baillie N, Rasmussen P. Black and blue cohosh in labour. N.Z.Med.J. 1-24-1997;110(1036):20-21.
Edmunds J. Blue cohosh and newborn myocardial infarction? Midwifery Today Int.Midwife. 1999;(52):34-35.
Finkel RS, Zarlengo KM. Blue cohosh and perinatal stroke. N.Engl.J.Med. 7-15-2004;351(3):302-303.
Ganzera M, Dharmaratne HR, Nanayakkara NP, et al. Determination of saponins and alkaloids in Caulophyllum thalictroides (blue cohosh) by high-performance liquid chromatography and evaporative light scattering detection. Phytochem.Anal. 2003;14(1):1-7.
Gunn TR, Wright IM. The use of black and blue cohosh in labour. N.Z.Med.J. 10-25-1996;109(1032):410-411.
Jhoo JW, Sang S, He K, et al. Characterization of the triterpene saponins of the roots and rhizomes of blue cohosh (Caulophyllum thalictroides). J.Agric.Food Chem. 2001;49(12):5969-5974.
Jones TK, Lawson BM. Profound neonatal congestive heart failure caused by maternal consumption of blue cohosh herbal medication. J.Pediatr. 1998;132(3 Pt 1):550-552.
Kennelly EJ, Flynn TJ, Mazzola EP, et al. Detecting potential teratogenic alkaloids from blue cohosh rhizomes using an in vitro rat embryo culture. J.Nat.Prod. 1999;62(10):1385-1389.
Lin LT, Liu LT, Chiang LC, et al. In vitro anti-hepatoma activity of fifteen natural medicines from Canada. Phytother Res 2002;16(5):440-444.
Low DT. Blue cohosh and neonatal myocardial toxicity. Journal of the American Herbalists Guild 2001;2(2):9-10.
McFarlin BL, Gibson MH, O'Rear J, et al. A national survey of herbal preparation use by nurse-midwives for labor stimulation. Review of the literature and recommendations for practice. J.Nurse Midwifery 1999;44(3):205-216.
Rao RB, Hoffman RS. Nicotinic toxicity from tincture of blue cohosh (Caulophyllum thalictroides) used as an abortifacient. Vet.Hum.Toxicol. 2002;44(4):221-222.
Reichert R. Neonatal congestive heart failure associated with maternal use of blue cohosh. Quarterly Review of Natural Medicine 1998;Winter:265-267.
Scott CC, Chen KK. The pharmacological action of n-methylcytisine. The Journal of Pharmacology and Experimental Therapuetics 1943;79:334-339.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.