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Piper nigrum (generic name)

treats Smoking cessation and Stroke recovery
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This information is based on a systematic review of scientific literature, and was peer-reviewed and edited by contributors to the Natural Standard Research Collaboration ( Dawn Costa, BA, BS (Natural Standard Research Collaboration); Nicole Giese, MS (Natural Standard Research Collaboration); Emily Kyomitmaitee, PharmD (University of Rhode Island); Tera Stock, PharmD (Massachusetts College of Pharmacy and Health Sciences); Shaina Tanguay-Colucci, BS (Natural Standard Research Collaboration); Catherine Ulbricht, PharmD (Massachusetts General Hospital); Wendy Weissner, BA (Natural Standard Research Collaboration).


DISCLAIMER: Natural Standard developed the above evidence-based information based on a thorough systematic review of the available scientific articles. For comprehensive information about alternative and complementary therapies on the professional level, go to Selected references are listed below.

Arias Irigoyen J, Talavera Fabuel A, Maranon Lizana F. Occupational rhinoconjunctivitis from white pepper. J Investig Allergol Clin Immunol 2003;13(3):213-215.

Chaudhry NM, Tariq P. Bactericidal activity of black pepper, bay leaf, aniseed and coriander against oral isolates. Pak J Pharm Sci 2006;19(3):214-218.

D'Souza P, Amit A, Saxena VS, et al. Antioxidant properties of Aller-7, a novel polyherbal formulation for allergic rhinitis. Drugs Exp Clin Res 2004;30(3):99-109.

Ebihara T, Ebihara S, Maruyama M, et al. A randomized trial of olfactory stimulation using black pepper oil in older people with swallowing dysfunction. J Am Geriatr Soc 2006;54(9):1401-1406.

Fazekas B, Tar A, Kovacs M. Aflatoxin and ochratoxin A content of spices in Hungary. Food Addit Contam 2005;22(9):856-863.

Hu Z, Yang X, Ho PC, et al. Herb-drug interactions: a literature review. Drugs 2005;65(9):1239-1282.

Ingkaninan K, Temkitthawon P, Chuenchom K, et al. Screening for acetylcholinesterase inhibitory activity in plants used in Thai traditional rejuvenating and neurotonic remedies. J Ethnopharmacol 2003;89(2-3):261-264.

Lambert JD, Hong J, Kim DH, et al. Piperine enhances the bioavailability of the tea polyphenol (-)-epigallocatechin-3-gallate in mice. J Nutr 2004;134(8):1948-1952.

McNamara FN, Randall A, Gunthorpe MJ. Effects of piperine, the pungent component of black pepper, at the human vanilloid receptor (TRPV1). Br J Pharmacol 2005;144(6):781-790.

O'Mahony R, Al Khtheeri H, Weerasekera D, et al. Bactericidal and anti-adhesive properties of culinary and medicinal plants against Helicobacter pylori. World J Gastroenterol 12-21-2005;11(47):7499-7507.

Pattanaik S, Hota D, Prabhakar S, et al. Effect of piperine on the steady-state pharmacokinetics of phenytoin in patients with epilepsy. Phytother Res 2006;20(8):683-686.

Pratibha N, Saxena VS, Amit A, et al. Anti-inflammatory activities of Aller-7, a novel polyherbal formulation for allergic rhinitis. Int J Tissue React 2004;26(1-2):43-51.

Siddiqui BS, Gulzar T, Begum S, et al. Piptigrine, a new insecticidal amide from Piper nigrum Linn. Nat Prod Res 2004;18(5):473-477.

Subehan Usia T, Kadota S, Tezuka Y. Mechanism-based inhibition of human liver microsomal cytochrome P450 2D6 (CYP2D6) by alkamides of Piper nigrum. Planta Med 2006;72(6):527-532.

Westerterp-Plantenga M, Diepvens K, Joosen AM, et al. Metabolic effects of spices, teas, and caffeine. Physiol Behav 8-30-2006;89(1):85-91.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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