Bacopa monniera Linn., Bacopa monniera Wettst., Bacopa monnieri, Bacopa monnieri L., bacopasapponin, bacopasaponin C, bacoside, bacoside A, bacoside A3, bacoside B, bacosine, betulinic acid, brahmi, Herpestis moniera cuneifolia, Herpestis monniera, Jalanimba, Jalnaveri, medhya rasayana, Moniera cuneifolia, oroxindin, sambrani chettu, Scrophulariaceae (family), thyme-leaved gratiola, water hyssop, wogonin.
Bacopa (Bacopa monnieri) leaf extract is called brahmi in Ayurvedic medicine and is widely used in India, especially for enhancing memory, analgesia (pain relief), and epilepsy. Bacopa has traditionally been used to treat asthma, hoarseness, and mental disorders, to help improve mental performance, epilepsy, and as a nerve tonic, cardiotonic (heart tonic), and diuretic (increases urine flow). Bacopa was prominently mentioned in Indian texts as early as the 6th Century.
Most research on bacopa has concentrated on its effects on learning. Bacopa may also be helpful in managing pediatric attention deficit hyperactivity disorder (ADHD), but clinical evidence is lacking.
Although bacopa is traditionally used in Ayurvedic medicine to enhance cognition, current evidence is lacking in this area. More research is needed before bacopa can be recommended for enhancing brain function in adults or children.
Bacopa has traditionally been used in Ayurvedic medicine to treat anxiety. Although early evidence is promising, more study is needed.
Although bacopa is traditionally used in Ayurvedic medicine for epilepsy, additional study is needed before a strong recommendation can be made.
Irritable bowel syndrome (IBS):
Preliminary evidence suggests that bacopa and bael fruit used in combination may treat irritable bowel syndrome (IBS). However, additional studies using bacopa alone are needed before bacopa can be recommended for IBS.
Although bacopa is traditionally used in Ayurvedic medicine to enhance memory, additional study is needed before a firm conclusion can be drawn.
There is no proven safe or effective dose for bacopa in adults. According to tradition, 50-150 milligrams two or three times a day has been used. For anxiety, 30 milliliters of bacopa syrup per day in two divided doses (representing 12 grams of dry crude drug) for four weeks has been used. Other preparations that have been used include 2 ounces of crude aqueous extract of bacopa daily for up to five months or 2-4 milligrams per kilogram of body weight of defatted alcoholic bacopa extract dissolved in distilled water daily for up to five months.
There is no proven safe or effective dose for bacopa in children. Nevertheless, based on traditional use, 350 milligrams per teaspoonful of dried plant extracted in a syrup has been taken three times daily for three months in children ages six to eight.
Avoid in individuals with a known allergy or hypersensitivity to Bacopa monnieri, its constituents, or any member of the Scrophulariaceae (figwort) family.
Side effects of bacopa may include nausea, dry mouth, thirst, and fatigue. Bacopa has been reported to cause palpitations (irregular heartbeats); patients with heart problems should use with caution.
Use cautiously in patients taking drugs or herbs that are metabolized by cytochrome P450 enzymes, as bacopa may negatively affect these enzymes.
Use cautiously in patients taking thyroid drugs, as bacopa may increase thyroid hormones.
Use cautiously in patients taking calcium blocking drugs, as bacopa may additively interact with them.
Use cautiously in patients taking sedatives, as bacopa may additively interact with them.
Bacopa is not recommended in pregnant or breastfeeding women due to a lack of available scientific evidence.
Bacopa may additively interact with calcium blocking drugs. Caution is advised.
Bacopa may negatively affect cytochrome P450 enzymes and may interfere with the way the body processes certain drugs. As a result, the levels of these drugs may be altered in the blood. Patients taking any medications should check the package insert and consult with a qualified healthcare professional, including a pharmacist, about possible interactions.
Bacopa may increase thyroid hormones and could interact additively with hypothyroid medicine.
Bacopa, when taken concomitantly with phenytoin, may reverse phenytoin-induced cognitive impairment. Consult with a qualified healthcare professional, including a pharmacist, to check for interactions.
Bacopa may negatively affect cytochrome P450 enzymes and interfere with the way the body processes certain herbs or supplements. As a result, the levels of other herbs or supplements may become too high in the blood. It may also alter the effects that other herbs or supplement possibly have on the P450 system.
This information is based on a systematic review of scientific literature edited and peer-reviewed by contributors to the Natural Standard Research Collaboration (www.naturalstandard.com): J. Kathryn Bryan, BA (Natural Standard Research Collaboration); Nicole Giese, MS (Natural Standard Research Collaboration); Shaina Tanguay-Colucci, BS (Natural Standard Research Collaboration); Verda Tunaligil, MD, MPH (Harvard School of Public Health); Catherine Ulbricht, PharmD (Massachusetts General Hospital); Wendy Weissner, BA (Natural Standard Research Collaboration).