Arabinoxylane, Arctostaphylos uva-ursi, AX, BioBran®, cinnaman AX, Cinnamomum cassia, Ganoderma lucidum, Hyphomycetes mycelia, kawaratake mushroom, MGN-3, rice bran, shiitake mushroom, suehirotake mushroom.
Altering the outer shell of rice bran using enzymes from Hyphomycetes mycelia mushroom extract produces Arabinoxylan compound. The product called MGN-3 (or BioBran® in Japan) is a complex containing arabinoxylan as a major component.
Arabinoxylan has been found to improve immune reactions in diabetes and cancer patients. MGN-3 may also be of potential value in treating AIDS patients or those patients undergoing chemotherapy. However, there is currently a lack of strong human scientific evidence to support the use of arabinoxylan for any indication.
Although presented by manufacturers as a generally safe substance without side effects at recommended doses, the United States Food and Drug Administration (FDA) ordered a permanent court order in 2004 against the marketing of MGN-3, charging that it has been promoted as a drug treatment for cancer, diabetes and HIV.
Cancer (various types):
Arabinoxylan has been studied in the treatment of cancer. Additional study is needed in this area.
Diabetes (type 2):
There is currently a lack of scientific evidence investigating the role of arabinoxylan in diabetics. More study is needed before a firm recommendation can be made.
In general, 600 milligrams a day in a divided dose has been used for daily health maintenance. The following doses have been used in scientific study, but are not proven effective or safe. For cancer, 3 grams of MGN-3 has been taken daily for up to six months in patients with different types of malignancies (such as multiple myeloma, leukemia, and cancers of the prostate, breast, cervix). Doses of 15, 30, and 45 milligrams per kilogram of MGN-3 have also been taken daily for two months.
For diabetes, 1-12 grams of arabinoxylan-rich fiber has been used daily.
There is currently a lack of available scientific evidence to recommend the use of arabinoxylan in children.