Mesoglycan (generic name)
treats Atherosclerosis, Vein clots, Intermittent claudication, Chronic venous ulcers, Venous disorders, and Cerebral ischemia
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This information is based on a systematic review of scientific literature, and was peer-reviewed and edited by contributors to the Natural Standard Research Collaboration (www.naturalstandard.com): Brent Bauer, MD (Mayo Clinic); Ashley Brigham, PharmD (Northeastern University); J. Kathryn Bryan, BA (Natural Standard Research Collaboration); Nicole Giese, MS (Natural Standard Research Collaboration); Juliann Goodfriend, PharmD (Northeastern University); Thuy-Duong Le, PharmD (Oregon State University); Jason Mahoney, BA (Natural Standard Research Collaboration); Audrey Nealon, PharmD (Northeastern University); Todd Porter, PhD (University of Kentucky); Rebecca Strauss, PharmD (Northeastern University); Shaina Tanguay-Colucci, BS (Natural Standard Research Collaboration); Kenneth Triptow, PharmD (Drake University); Wendy Weissner, BA (Natural Standard Research Collaboration).
BibliographyDISCLAIMER: Natural Standard developed the above evidence-based information based on a thorough systematic review of the available scientific articles. For comprehensive information about alternative and complementary therapies on the professional level, go to www.naturalstandard.com. Selected references are listed below.
Ambrosio LA, Marchese G, Filippo A, et al. The effect of mesoglycan in patients with cerebrovascular disease: a psychometric evaluation. J Int Med Res 1993;21(3):138-146.
Arosio E, Ferrari G, Santoro L, et al. A placebo-controlled, double-blind study of mesoglycan in the treatment of chronic venous ulcers. Eur J Vasc Endovasc Surg 2001;22(4):365-372.
Bettini R, Maino C, Gorini M. [Effectiveness of mesoglycan in the prevention of cerebral ischemia]. Clin Ter 2003;154(1):13-16.
Blardi P, Messa G, Puccetti L, et al. [Effects on the coagulation-fibrinolysis system of a single oral dose of mesoglycan at the beginning and at the end of a prolonged treatment in man]. Recenti Prog.Med. 1995;86(7-8):282-289.
Giorgetti PL, Marenghi MC, Bianciardi P. [Heparan sulfate in the therapy of postphlebitic syndrome. Evaluation of the efficacy and tolerability as compared to mesoglycan]. Minerva Cardioangiol. 1997;45(6):279-284.
Kobayashi T, Osakabe T, Seyama Y. Comparison of elastolytic activity between experimental aneurysm and experimental diabetes mellitus. Biol Pharm Bull. 1998;21(7):775-777.
La Marca G, Pumilia G, Martino A. [Effectiveness of mesoglycan topical treatment of leg ulcers in subjects with chronic venous insufficiency]. Minerva Cardioangiol. 1999;47(9):315-319.
Laurora G, Ambrosoli L, Cesarone MR, et al. Treatment of intermittent claudication with defibrotide or mesoglycan. A double blind study. Panminerva Med. 1994;36(2):83-86.
Maehira F, Zaha F, Miyagi I, et al. Effects of passive smoking on the regulation of rat aortic cholesteryl ester hydrolases by signal transduction. Lipids 2000;35(5):503-511.
Messa G, Blardi P, La Placa G, et al. [Effects of 2 single oral doses of mesoglycan on the coagulation-fibrinolysis system in man. A pharmacodynamic study]. Recenti Prog.Med. 1995;86(7-8):272-281.
Nenci GG, Gresele P, Ferrari G, et al. Treatment of intermittent claudication with mesoglycan--a placebo-controlled, double-blind study. Thromb.Haemost. 2001;86(5):1181-1187.
Raso AM, Maggio D, Trogolo M, et al. [Effectiveness of mesoglycan therapy in patients with ischemia of the lower limbs. Preliminary results of a new therapeutic protocol]. Minerva Cardioangiol. 1997;45(7-8):383-392.
Scondotto G, Catena G, Aloisi D. [Use of mesoglycan in venous pathology]. Minerva Med. 1997;88(12):537-541.
Tardieu M, Bourin MC, Desgranges P, et al. Mesoglycan and sulodexide act as stabilizers and protectors of fibroblast growth factors (FGFs). Growth Factors 1994;11(4):291-300.
Tovar AM, Cesar DC, Leta GC, et al. Age-related changes in populations of aortic glycosaminoglycans: species with low affinity for plasma low-density lipoproteins, and not species with high affinity, are preferentially affected. Arterioscler.Thromb.Vasc.Biol. 1998;18(4):604-614.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.