5-hydroxytryptophan (generic name)
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Authors/Editors: Tracee Abrams, PharmD (University of Rhode Island); Heather Boon, BScPhm, PhD (University of Toronto); Robert D'Alessandro, MS (Northeastern University); Nicole Giese, MS (Natural Standard Research Collaboration); Michael Goble, BS, PharmD (Massachusetts College of Pharmacy); Dana Hackman, BS (Northeastern University); Paul Hammerness, MD (Harvard Medical School); Sadaf Hashmi, MD, MPh (Johns Hopkins School of Hygiene and Public Health); Lisa Scully, PharmD (Massachusetts College of Pharmacy); Erica Seamon, PharmD (Nova Southeastern University); Michael Smith, MRPharmS, ND (Canadian College of Naturopathic Medicine); Shaina Tanguay-Colucci, BS (Natural Standard Research Collaboration); Candy Tsourounis, PharmD (University of California); Catherine Ulbricht, PharmD (Massachusetts General Hospital); Mamta Vora, PharmD (Natural Standard Research Collaboration); Wendy Weissner, BA (Natural Standard Research Collaboration).
BibliographyDISCLAIMER: Natural Standard developed the above evidence-based information based on a thorough systematic review of the available scientific articles. For comprehensive information about alternative and complementary therapies on the professional level, go to www.naturalstandard.com. Selected references are listed below.
Angst J, Woggon B, Schoepf J. The treatment of depression with L-5-hydroxytryptophan versus imipramine. Results of two open and one double-blind study. Arch Psychiatr Nervenkr 10-11-1977;224(2):175-186.
Bagdy G, Kecskemeti V, Riba P, et al. Serotonin and epilepsy. J Neurochem 2007;100(4):857-873.
Belongia EA, Hedberg CW, Gleich GJ, et al. An investigation of the cause of the eosinophilia-myalgia syndrome associated with tryptophan use. The New England Journal of Medicine 8-9-1990;323(6):357-365.
Birdsall, T. C. 5-Hydroxytryptophan: a clinically-effective serotonin precursor. Altern Med Rev 1998;3(4):271-280.
Bono G, Micieli G, Sances, G, et al. L-5HTP treatment in primary headaches: an attempt at clinical identification of responsive patients. Cephalalgia 1984;4(3):159-165.
Caruso I, Sarzi Puttini P, Cazzola M, et al. Double-blind study of 5-hydroxytryptophan versus placebo in the treatment of primary fibromyalgia syndrome. J Int Med Res. 1990;18(3):201-209.
De Giorgis G, Miletto R, Iannuccelli M, et al. Headache in association with sleep disorders in children: a psychodiagnostic evaluation and controlled clinical study--L-5-HTP versus placebo. Drugs Exp Clin Res. 1987;13(7):425-433.
Eriksson O, Wall A, Marteinsdottir I, et al. Mood changes correlate to changes in brain serotonin precursor trapping in women with premenstrual dysphoria. Psychiatry Res 3-31-2006;146(2):107-116.
Halford JC, Harrold JA, Boyland EJ, et al. Serotonergic drugs : effects on appetite expression and use for the treatment of obesity. Drugs 2007;67(1):27-55.
Poldinger W, Calanchini B, Schwarz W. A functional-dimensional approach to depression: serotonin deficiency as a target syndrome in a comparison of 5-hydroxytryptophan and fluvoxamine. Psychopathology 1991;24(2):53-81.
Puttini PS, Caruso I. Primary fibromyalgia syndrome and 5-hydroxy-L-tryptophan: a 90-day open study. J Int Med Res 1992;20(2):182-189.
Shaw K, Turner J, Del Mar C. Tryptophan and 5-hydroxytryptophan for depression. Cochrane Database Syst Rev 2002;(1):CD003198.
Thomson J, Rankin H, Ashcroft GW, et al. The treatment of depression in general practice: a comparison of L- tryptophan, amitriptyline, and a combination of L-tryptophan and amitriptyline with placebo. Psychol Med 1982;12(4):741-751.
Titus F, Davalos A, Alom J, et al. 5-Hydroxytryptophan versus methysergide in the prophylaxis of migraine. Randomized clinical trial. Eur Neurol 1986;25(5):327-329.
Trouillas P, Brudon F, Adeleine P. Improvement of cerebellar ataxia with levorotatory form of 5- hydroxytryptophan. A double-blind study with quantified data processing. Arch.Neurol 1988;45(11):1217-1222.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.