Korlym Approved for Cushing's Syndrome

powered by healthline

Average Ratings

Blocks effects of too much cortisol, the so-called 'stress' hormone

MONDAY, Feb. 20 (HealthDay News) -- Korlym (mifepristone) has been approved by the U.S. Food and Drug Administration to treat endogenous Cushing's syndrome, a disabling disorder caused by overproduction of the so-called "stress hormone," cortisol.

Cortisol is produced by the adrenal glands and increases blood sugar, making it particularly dangerous for people with diabetes. Korlym does not decrease production of the hormone, but reduces the effects of overproduction, the FDA said in a news release.

The approval is for people with endogenous (of internal cause) Cushing's syndrome who have type 2 diabetes and who either haven't responded to previous surgery or aren't candidates for new surgery. Only about 5,000 people in the United States are likely to be eligible for the drug, the agency said.

The medication was evaluated in clinical studies involving 50 people. Participants who took Korlym had "significant improvement in blood sugar control," the FDA said.

Although the chances of a person with Cushing's syndrome becoming pregnant are slim, Korlym 's label warns that the drug should never be used by expectant women, since it is likely to "terminate a pregnancy," the agency said.

Common side effects observed during clinical testing included nausea and vomiting, fatigue, headache, swelling of the extremities, dizziness and loss of appetite.

Korlym is produced by Corcept Therapeutics, based in Menlo Park, Calif.

More information

To learn more about Cushing's, visit Medline Plus.

-- Scott Roberts
Copyright © 2012 HealthDay. All rights reserved.
Article from
Top of page
General Drug Tools
General Drug Tools view all tools
Tools for
Healthy Living
Tools for Healthy Living view all tools
Search Tools
Search Tools view all tools
Insurance Plan Tools
Insurance Plan Tools view all tools

What is a reference number?

When you register on this site, you are assigned a reference number. This number contains your profile information and helps UnitedHealthcare identify you when you come back to the site.

If you searched for a plan on this site in a previous session, you might already have a reference number. This number will contain any information you saved about plans and prescription drugs. To use that reference number, click on the "Change or view saved information" link below.

You can retrieve information from previous visits to this site, such as saved drug lists and Plan Selector information.