Thallium Stress Test
A thallium stress test is a nuclear imaging test that shows how well blood flows into the heart while you're exercising or at rest, using nucle...

Table of Contents
powered by healthline

Average Ratings

What Is a Thallium Stress Test?

A thallium stress test is a nuclear imaging test that shows how well blood flows into the heart while you’re exercising or at rest. This test is also called a cardiac or nuclear stress test.

During the procedure, a radioisotope (nuclear liquid) is administered through an IV. The radioisotope will flow through your blood stream and end up in your heart. Once the radiation is in your heart, a special camera called a gamma camera can detect the radiation and reveal any issues your heart muscle is having.

Your doctor may order a thallium for a variety of reasons, including:

  • if they suspect your heart isn’t getting enough blood flow (oxygen) when it’s under stress (exercise)
  • if you have chest pain or worsening angina
  • if you’ve had a previous heart attack
  • to check how well medications are working
  • to determine whether or not a procedure or surgery was successful
  • to determine if your heart is healthy enough to start an exercise program

The thallium stress test can show:

  • the size of the heart chambers
  • how effectively the heart pumps (ventricular function)
  • how well the coronary arteries supply the heart with blood (myocardial perfusion)
  • if the heart muscle is damaged or scarred from previous heart attacks

How Is a Thallium Stress Test Performed?

The test must be done at a hospital, medical center, or doctor’s office. A nurse or healthcare professional will insert an IV usually on the inside of the elbow. A radioisotope or radiopharmaceutical medication such as thallium or sestamibi is injected through the IV.

The nuclear material will mark your blood flow and will be picked up by the gamma camera.

The test will include an exercise and resting portion, and your heart will be photographed during both. The doctor administering your test will determine the order that these tests are performed in. You’ll receive an injection of the medication before each portion.

Resting Portion

You’ll lie down for 15 to 45 minutes while the medication works its way through your body to your heart. You’ll then lie down on an exam table with your arms above your head and a gamma camera above you will take pictures.

Exercise Portion

In the exercise portion of the test, you’ll walk on a treadmill or pedal an exercise bicycle. Most likely, your doctor will ask you to start slowly and progressively pick up the pace into a jog. You may need to run on an incline to make it more challenging.

If you’re unable to exercise, your doctor will give you a medication that will stimulate your heart and make it beat faster. This simulates how your heart would act during exercise.

Your blood pressure and heart rhythm are monitored while you exercise. Once your heart is working as hard as it can, you’ll get off the treadmill. After about 30 minutes, you’ll lie down on an exam table again.

The gamma camera will record pictures that show the flow of blood through your heart. Your doctor will compare these pictures with the set of resting images to evaluate how weak or strong the blood flow to your heart is.

How to Prepare for a Thallium Stress Test

You’ll probably need to fast after midnight the night before the test or at least 4 hours before the test. Fasting can prevent getting sick during the exercise portion. Wear comfortable clothes and shoes for exercising.

Twenty-four hours before the test, you’ll need to avoid all caffeine — even decaffeinated coffee and drinks have small amounts of caffeine — including tea, soda, coffee, chocolate, and certain pain relievers. Drinking caffeine can cause your heart rate to be higher than it normally would be.

Your doctor will need to know all medications that you’re taking. This is because some medications — like ones that treat asthma — can interfere with your test results. Your doctor will also want to know if you’ve taken any erectile dysfunction medication including Viagra, Cialis, or Levitra 24 hours before the test.

Risks and Complications of a Thallium Stress Test

Most people tolerate the test very well. You may feel a sting as the medication that simulates exercise is injected, followed by a warm feeling. Some people may experience headache, nausea, and a racing heart.

The nuclear material will leave your body through your urine. Complications from the nuclear material injected into your body are very rare.

Rare complications from the test may include:

  • arrhythmias (irregular heart beat)
  • increased angina (pain from poor blood flow in the heart)
  • difficulty breathing
  • asthma-like symptoms
  • large swings in blood pressure
  • skin rashes
  • shortness of breath
  • chest discomfort
  • dizziness
  • heart palpitations (an irregular heart beat)

Alert the test administrator if you experience any of these symptoms during your test.

What Do Results of the Thallium Stress Test Mean?

Results depend on the reason for the test, how old you are, your history of heart problems, and other medical issues.

Normal Results

A normal result means blood flowing through the coronary arteries in the heart is normal.

Abnormal Results

Abnormal results may indicate:

  • reduced blood flow to part of the heart (narrowing or blockage of one or more arteries that supply your heart muscle)
  • scarring of the heart muscle due to a previous heart attack
  • coronary artery disease (heart disease)
  • a too-large heart (indicating other heart complications)

Your doctor may need to order more tests to determine if you have a heart condition. Your doctor will develop a treatment plan specifically for you, based on the results of this test. 

Written by: Jennifer Nelson
Edited by:
Medically Reviewed by: [Ljava.lang.Object;@6ad58e05
Published: Jun 4, 2012
Published By: Healthline Networks, Inc.
Top of page
General Drug Tools
General Drug Tools view all tools
Tools for
Healthy Living
Tools for Healthy Living view all tools
Search Tools
Search Tools view all tools
Insurance Plan Tools
Insurance Plan Tools view all tools