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RPR Test
A rapid plasma reagin test is used to screen you for syphilis. It detects the antibodies that your body produces to fight the infection.

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What Is a Rapid Plasma Reagin (RPR) Test?

A rapid plasma reagin (RPR) test is a blood test used to screen you for syphilis. It works by detecting the antibodies that your body produces to fight the infection.

Syphilis is a sexually transmitted infection (STI) that can be fatal if left untreated. The RPR test allows your doctor to confirm the diagnosis and start your treatment. This reduces the chances of complications and the spread of the disease by an infected but unaware person.

When Is an RPR Test Recommended?

Your doctor may order an RPR test for several reasons. It’s a quick way to screen those at high risk for syphilis. Your doctor may also order this test if you have syphilis-like sores or a rash. Doctors also routinely screen pregnant women for syphilis using an RPR test.

A few states still require that people who are applying for a marriage certificate get a screening test for syphilis. These states include Mississippi, Montana, and the District of Columbia.

The RPR test measures antibodies to the disease rather than the disease itself. It can also be used to check the progress of treatment for syphilis. After a course of antibiotics, your doctor would expect to see the number of antibodies drop and an RPR test could confirm this.

How Is Blood for the RPR Test Obtained?

Doctors obtain blood for the RPR test with a simple blood test called a venipuncture. This can be done in your doctor’s office or a lab. You don’t need to fast or take any other special measures before this test. The test involves the following steps:

  1. A healthcare provider will ask you to sit in a comfortable chair or lie down on a cot or a gurney.
  2. They then tie rubber tubing around your upper arm to help make your veins stand out. When they find your vein, they swab the spot with rubbing alcohol to cleanse it and insert a needle into the vein. The needle may produce a sudden, sharp pain, but it typically doesn’t last long.
  3. Once they have the blood sample, they’ll remove the needle from your vein, hold pressure on the puncture site for a few seconds, and offer you a bandage.

Risks of the RPR Test

Venipuncture is minimally invasive and carries very few risks. Some people complain of soreness, bleeding, or bruising after the test. You can apply an ice pack to the puncture wound to help relieve these symptoms.

Some people may become light-headed or dizzy during the test. Tell the healthcare provider if your dizziness lasts longer than a few minutes.

Understanding Your Results

A normal blood sample shows no antibodies to syphilis. However, your doctor cannot completely rule out syphilis if they see no antibodies. Once you’ve been infected, it takes some time for your immune system to create antibodies to fight the bacteria. Shortly after infection, a test may not show any antibodies. This is known as a false negative.

False negatives tend to be more common in the initial and end stages of infection. Among people who are in the second or middle stage of infection, the RPR test results are nearly always accurate.

The RPR test also can produce false-positive results, suggesting you have syphilis when you actually don’t. One reason for a false positive is the presence of another disease that produces antibodies similar to the ones that fight syphilis. A few of the conditions that can cause a false positive include:

  • HIV
  • Lyme disease
  • malaria
  • lupus
  • certain types of pneumonia, especially those associated with a compromised immune system

Your doctor may ask you to wait a few weeks and then return for another test if you show symptoms of syphilis but you have a negative RPR test. This is because of the RPR test’s potential for a false negative.

Due to the risk of false-positive results, your doctor will confirm the presence of syphilis with a second test before starting your treatment. This test is called the fluorescent treponemal antibody-absorption (FTA-ABS) test.

Follow-Up After the RPR Test

Your doctor will start you on a course of antibiotics, usually penicillin, if your RPR and FTA-ABS test both show signs of syphilis. New infections usually respond to treatment quickly.

At the end of treatment, the doctor will probably recommend that you get another RPR test to make sure your antibody levels are dropping.

Written by: Debra Stang
Edited by:
Medically Reviewed by:
Published: Jul 11, 2012
Published By: Healthline Networks, Inc.
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