What Is Opiate Withdrawal?
Opiates are a class of drugs that are commonly prescribed to
treat pain. Prescription opiates include:
- Oxycontin (oxycodone)
- Vicodin (hydrocodone and acetaminophen)
- Dilaudid (hydromorphone)
- Morphine sulfate
Although very useful to treat pain, these drugs can cause physical
dependency and addiction. According to the National
Institute on Drug Abuse, approximately 2.1 million people in the United
States and between 26.4 and 36 million people worldwide abuse opioids.
Certain illegal drugs, such as heroin, are also opiates.
Methadone is an opiate that is often prescribed to treat pain, but may also be
used to treat withdrawal symptoms in people who have become addicted to
If you stop or decrease the amount of opiates you’re taking, you
may experience physical symptoms of withdrawal. This is especially true if you’ve
been using these medications at high doses for more than a few weeks. Many
systems in your body are altered when you take large amounts of opiates for a
long time. Withdrawal effects occur because it takes time for your body to
adjust to no longer having opiates in your system.
Opiate withdrawal can be categorized as mild, moderate,
moderately severe, and severe. Your primary care provider can determine this by
evaluating your opiate use history and symptoms, and by using diagnostic tools
like the Clinical
Opiate Withdrawal Scale.
What Effect Do Opiates Have on the Body?
Opiates attach themselves to opiate receptors in the brain,
spinal cord, and the gastrointestinal tract. Whenever opiates attach to these
receptors, they exert their effects. Opioid receptors naturally occur in the
brain and the brain actually manufactures its own opioids, which are
responsible for a whole host of effects including decreasing pain, lowering the
respiratory rate, and even antianxiety and antidepressant effects. However, the
body does not produce opioids in large quantities — that is, enough to treat
the pain associated with a broken leg. Also, the body never produces opioids in
large enough quantities to cause an overdose. Taking opioids (either
prescription or illicit) mimics these naturally occurring opioids.
The impact of these drugs include:
may affect the brainstem, which controls functions like breathing and
heartbeat, by slowing breathing or reducing coughing.
may act on specific areas of the brain known as the limbic system, which
controls emotions, to create feelings of pleasure or relaxation.
work to reduce pain by affecting the spinal cord, which sends messages from the
brain to the rest of the body, and vice versa.
What Causes Opiate
When you take opiate medication for a long time, your body
becomes desensitized to the effects. Over time, your body needs more and more
of the drug to achieve the same effect. This can be very dangerous and
increases risk of accidental overdose.
Prolonged use of these drugs changes the way nerve receptors work
in your brain, and these receptors become dependent upon the drug to function. If
you become physically sick after you stop taking an opiate medication, it may
be an indication that you’re physically dependent on the substance. Withdrawal
symptoms are the body’s physical response to the absence of the drug.
Many people become dependent on these drugs in order to avoid
pain or withdrawal symptoms. In some cases, many people don’t even realize that
they’ve become dependent and often mistake withdrawal for symptoms of the flu
or another condition.
What Are the Symptoms of
The symptoms you experience will depend on the level of withdrawal
you are experiencing. Also, multiple factors dictate how long a person will
experience the symptoms of withdrawal. Because of this, everyone experiences
opiate withdrawal differently. However, there’s typically a timeline for the
progression of symptoms.
Early symptoms typically begin in the first 24 hours after you
stop using the drug, and they include:
(eyes tearing up)
Later symptoms, which can be more intense, begin after the first
day or so. They include:
bumps on the skin
pupils and possibly blurry vision
Although very unpleasant and painful, symptoms usually begin to
improve within 72 hours, and within a week you should almost be back to normal.
Babies born to mothers who are addicted to or have used opiates
while pregnant often experience withdrawal symptoms as well. These may include:
- digestive issues
- poor feeding
It’s important to remember that different drugs remain in your
system for different lengths of time and this can affect withdrawal onset. The
amount of time your symptoms last depends on the frequency of use and severity
of the addiction, as well as individual factors like your overall health.
For example, heroin is typically eliminated from your system
faster, and symptoms will start within 12 hours of last use. If you’ve been on
methadone, it may take a day and a half for symptoms to begin.
Some specialists point out that recovery requires at least a
period of six months of total abstinence during which the person may still
experience symptoms of withdrawal. This is sometimes referred to as “protracted
abstinence.” It’s important to discuss ongoing symptoms with your healthcare
How Is Opiate Withdrawal
To diagnose opiate withdrawal, your primary care provider will
perform a physical examination and ask questions about your symptoms. They may
also order urine and blood tests to check for the presence of opiates in your
You may be asked questions about past drug use and your medical
history. Answer openly and honestly to get the best treatment and support.
What Treatments Are
Available for Opiate Withdrawal?
Opiate withdrawal can be very uncomfortable, and many people
continue taking these drugs to avoid unpleasant symptoms, or they try to manage
these symptoms on their own. However, medical treatment in a controlled
environment can make you more comfortable and lead to a greater chance of
Mild withdrawal can be treated with acetaminophen (Tylenol),
aspirin, or nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen.
Plenty of fluids and rest are important. Medications such as loperamide (Imodium)
can help with diarrhea and hydroxyzine (Vistaril, Atarax) may ease nausea.
More intense withdrawal symptoms may require hospitalization and
other medications. One medication used primarily in the inpatient setting is clonidine.
Clonidine can help reduce the intensity of withdrawal symptoms by 50 to 75
percent. Clonidine is especially effective at reducing:
- muscle aches
- runny nose
Suboxone is a combination of a milder opiate (buprenorphine) and an opiate blocker (naloxone) that
does not produce many of the addictive effects of other opiates. The opiate blocker works mostly in
the stomach to prevent constipation. If injected it will cause immediate
withdrawal, so the combination is less likely to be abused than other
formulations. When taken by mouth, this combination can be used to treat symptoms of
withdrawal and can shorten the intensity and length of detoxification from
other, more dangerous, opiates.
Methadone can be used for long-term maintenance therapy. It’s
still a powerful opiate, but it can be reduced in a controlled manner that is
less likely to produce intense withdrawal symptoms.
Rapid detoxification is rarely done. It is done under anesthesia
with opiate-blocking drugs, such as naloxone or naltrexone. There’s some
evidence that this method decreases symptoms, but doesn’t necessarily impact
the amount of time spent in withdrawal. Additionally, because vomiting often
occurs during withdrawal, the potential of vomiting under anesthesia greatly
increases the risk of death. Because of this, most doctors hesitate to use this
method, as the risks outweigh the potential benefits.
What Are the Complications
of Opiate Withdrawal?
vomiting can be significant symptoms during the withdrawal process. Inadvertent
breathing of vomited material into the lungs (known as aspiration) can be a
serious complication associated with withdrawal, as it can lead to the
development of pneumonia (aspiration pneumonia).
another very uncomfortable and potentially dangerous withdrawal symptom. Loss
of fluids and electrolytes from diarrhea can cause the heart to beat in an
abnormal manner, which can lead to circulatory problems and even heart attack. It’s
important to replace fluids lost to vomiting and diarrhea to prevent these
Even if you don’t
experience vomiting, nausea can be very uncomfortable. Muscle cramps and joint
pain can also be present during opiate withdrawal. The good news is that your
primary care provider can work with you by providing select medications that
can help with these uncomfortable withdrawal symptoms.
important to note that some individuals may experience other withdrawal
symptoms not listed here. This is why it’s important to work with your primary
care provider during the withdrawal period.
What Can I Expect in the
If you’ve stopped taking opiate medication and are experiencing
withdrawal symptoms, see your doctor as soon as possible. Your doctor can help
manage symptoms and adjust your medication regimen. You should not stop taking
prescribed opiate medication without the recommendation from your doctor.
Seeking help for an opiate addiction will improve your overall health
and reduce your risk of relapse, accidental overdose, and complications related
to opiate addiction. Talk to your doctor or healthcare provider about treatment
programs or support groups in your area. The overall improvement in physical
and mental health is worth the pain and discomfort of withdrawal.