Gastritis and duodenitis both refer to inflammation of the lining of parts of your digestive system. Both have the same causes and treatments.

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What Are Gastritis and Duodenitis?

Gastritis is inflammation of the stomach lining. Duodenitis is inflammation of the duodenum (the first part of the small intestine), which is located just below your stomach. Both gastritis and duodenitis have the same causes and treatments.

Both conditions may occur in men and women of all ages. The conditions may be acute or chronic. The acute forms come on suddenly and last for a short time. The chronic forms may progress slowly and last for months or years. The conditions are curable and generally don’t cause any long-term complications.

What Causes Gastritis and Duodenitis?

The most common cause of gastritis and duodenitis is a bacterium called Helicobacter pylori (H. pylori). Large amounts of the bacteria invading your stomach or small intestine can cause inflammation.

H. pylori can be transferred from person to person. It can also be transmitted through contaminated food and water, although this is uncommon in the United States. According to the National Digestive Diseases Information Clearinghouse, approximately 20 to 50 percent of people in the United States may be infected with H. pylori. In comparison, up to 80 percent of people in developing countries are infected with the bacteria.

Other common causes of gastritis and duodenitis include the long-term use of certain medications, such as aspirin, ibuprofen, or naproxen, or drinking too much alcohol.

Less common causes include:

  • Crohn’s disease (inflammation of the digestive tract)
  • an autoimmune condition (when the body makes antibodies that attack the cells lining the stomach) resulting in atrophic gastritis (destruction of stomach lining)
  • bile reflux (when bile flows from the duodenum into the stomach)
  • having certain viral infections — such as herpes simplex virus — along with a weak immune system
  • traumatic injury to your stomach or small intestine
  • being placed on a breathing machine
  • extreme stress caused by major surgery, severe body trauma, shock
  • ingesting caustic substances or poisons (strong substances that can burn or corrode your tissues if you swallow them)
  • excessive cigarette smoking
  • radiation therapy for cancer
  • chemotherapy for cancer

Gastritis, Duodenitis, and Inflammatory Bowel Disease

Inflammatory bowel disease (IBD) is the chronic inflammation of part or all of the digestive tract. The exact cause is unknown, but doctors believe that IBD may be the result of an immune disorder. It’s also possible that the disease is inherited. Examples of IBD include ulcerative colitis (inflammation of the colon and rectum) and Crohn’s disease. Crohn’s disease may affect any part of the digestive tract and often spreads beyond the intestinal lining and into other tissues.

A study published in Inflammatory Bowel Diseases reported that people with inflammatory bowel disease are much more likely to develop a form of gastritis or duodenitis that isn’t caused by H. pylori than people who don’t have the disease.

What Are the Symptoms of Gastritis and Duodenitis?

Gastritis and duodenitis don’t always produce signs or symptoms. When they do, common symptoms include:

  • nausea
  • vomiting
  • burning or cramping feeling in the stomach
  • indigestion
  • feeling full shortly after you begin eating

In some cases, feces may appear black in color and vomit may look like used coffee grounds. These symptoms can indicate internal bleeding. Call your doctor right away if you experience either of these symptoms.

How Are Gastritis and Duodenitis Diagnosed?

There are several tests your doctor can use to diagnose gastritis and duodenitis. H. pylori can be detected through blood, stool, or breath tests. For a breath test, you will be instructed to drink a clear, tasteless liquid and then breathe into a bag. This will help your doctor detect any extra carbon dioxide gas in your breath if you are infected with H. pylori.

Your doctor may also perform an upper endoscopy with biopsy. During this procedure, a small camera attached to a long, thin, flexible tube (an endoscope) is moved down the throat to look into the stomach or small intestine. This test will allow your doctor check for inflammation. Your doctor may take a few small tissue samples for further testing if any inflammation can’t be detected visually.

How Are Gastritis and Duodenitis Treated?

Depending on the cause of your condition, your symptoms may go away without treatment. The type of care you receive will depend on the cause and severity of your gastritis or duodenitis. Fastritis and duodenitis usually clear up without complications.


H. pylori infections are treated with antibiotics. Your doctor may recommend a combination of drugs to kill the infection, and most people will need to take antibiotics for two weeks or longer.

Acid Reducers

Over-the-counter acid blockers (drugs that work to reduce the amount of acid released into your digestive tract) may be recommended. These include:

  • cimetidine (Tagamet)
  • famotidine (Pepcid)
  • ranitidine (Zantac)

Proton pump inhibitors (drugs that block cells that produce acid) are also used to treat these conditions. These include:

  • esomeprazole (Nexium)
  • lansoprazole (Prevacid)
  • omeprazole (Prilosec)

Your doctor may prescribe prescription-strength acid reducers to keep stomach acid from irritating the lining of your digestive tract.


Your doctor may suggest antacids to neutralize stomach acid and relieve pain. These are over-the-counter and don’t need to be prescribed. Antacid options include:

  • calcium carbonate (Tums)
  • magnesium hydroxide (milk of magnesia)

calcium carbonate and magnesium hydroxide (Rolaids)

Antacids can prevent your body from absorbing other medications, so it is recommended that you take antacids at least an hour before other medications to avoid this side effect.

Lifestyle Changes

Avoid smoking, alcohol, spicy foods, acidic beverages (such as orange juice or pineapple juice), and medications (such as aspirin) that are hard on the stomach. All of these can make your symptoms worse.

When Should You Call Your Doctor?

Make an appointment with your doctor if your symptoms don’t go away with treatment. Call your doctor immediately if:

  • you have a fever of 100.4ºF or higher
  • your vomit looks like used coffee grounds
  • your feces are black or tarry
  • you have severe abdominal pain

Untreated cases of gastritis and duodenitis can become chronic. This can lead to stomach ulcers and stomach bleeding. In rare cases, extensive thinning of the stomach lining can change the cells over time and increase your risk of developing stomach cancer.

Talk to your doctor if your gastritis or duodenitis isn’t clearing up so you can determine the cause and make sure you get the treatment you need. 

Written by: Rose Kivi and Brian Wu
Edited by:
Medically Reviewed by: [Ljava.lang.Object;@3ae9cfc0
Published: Jul 20, 2012
Published By: Healthline Networks, Inc.
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