What is ademetionine?
Ademetionine is a form of the
amino acid methionine. It also is called S-adenosylmethionine, or SAMe.
Typically, a human body makes all
the ademetionine it needs for good health. However, low levels of methionine,
folate, or vitamin B-12 can cause a drop in ademetionine levels. Since this
chemical doesn’t exist in foods, a synthetic version is sometimes used to
normalize levels in the body.
Ademetionine is sold as a dietary
supplement in the United States. In Europe, it is used as a prescription drug.
What does ademetionine do?
SAMe plays a role in the immune
system, maintains cell membranes, and helps produce and break down brain
chemicals, such as serotonin, melatonin, and dopamine.
Additional but inconclusive
research suggests that it also may be useful for treating symptoms of:
of the liver
problems related to AIDS
(blocked bile flow from the liver to the gall bladder)
What are the side effects of ademetionine?
Ademetionine is safe for most
adults. However, it can sometimes cause the following side effects:
Patients with depression may feel
anxiety. An upset stomach can also occur when patients begin taking this
supplement. Starting with smaller doses and working up to a full dose can help
the body adjust.
Patients who are allergic to
ademetionine may have symptoms of an anaphylactic reaction. These symptoms include:
or reddening of the skin
How is ademetionine administered?
Ademetionine is made in oral and
intravenous forms. The Mayo Clinic reports that the following oral
dosages have been effective for some adults with the following conditions:
600 to 1,200 milligrams (mg) in one to three divided doses daily
up to 1,600 mg daily
800 to 1,600 mg daily
400 mg taken twice daily
disease: 600 to 1,200 mg daily
A full dose of ademetionine is
usually 400 mg, taken three or four times daily.
Ademetionine is not considered
safe for children.
What are the benefits of ademetionine?
Ademetionine is effective in
relieving the pain of osteoarthritis. The benefits of ademetionine for the
treatment of other conditions are uncertain. Some evidence suggests that it may
deficit hyperactivity disorder (ADHD) in adults
in both pregnant and nonpregnant patients
Ademitionine is used to treat
many other conditions, although there is insufficient evidence to determine
whether it is helpful for these conditions. Conditions for which ademitionine
is sometimes used include:
- premenstrual syndrome (PMS)
What are the risks of ademetionine?
Consult with a healthcare
provider before taking any medications, including herbs and supplements.
Ademetionine is considered safe
for most adults. However, it can worsen symptoms in patients with certain
disorders, such as bipolar disorder or Parkinson’s disease. Pregnant or breast-feeding
women should not take ademetionine.
Since it affects the central
nervous system, ademetionine may interfere with surgery. Its use should be
discontinued at least two weeks prior to surgery.
Ademetionine interacts with
serotonin, a chemical in your brain. When combined with medications that also
affect serotonin, ademetionine can increase the risk of serotonin syndrome.
This is a potentially serious condition caused by too much serotonin. Side
effects can include heart problems, shivering, and anxiety.
Ademetionine should not be taken
with the following medications:
(an active ingredient in many over-the-counter cough medicines)
oxidase inhibitors (MAOIs)
should not be taken with herbs and supplements that increase serotonin levels.
Ademetionine should not be taken
with diabetes medications because they may increase the effects of these drugs.
This can increase the risk of low blood sugar, or hypoglycemia.
How does a patient prepare for taking
An upset stomach and digestive
side effects can occur if you begin with the fully recommended dose. Starting
with smaller doses until side effects subside can help the body adjust.
What are the results of
is useful in relieving the pain of osteoarthritis. It seems to be as effective as
nonsteroidal anti-inflammatory drugs (NSAIDs) in treating this condition,
according to the Mayo Clinic.
However, there is not enough evidence on the use of ademetionine for
depression, fibromyalgia, and liver cholestasis. More information is needed to
recommend its use for treatment of these conditions.