iodine I 131 tositumomab (generic name)

This medicine allows radiation to target specific kinds of white blood cells
(TOE sih too MOE mab)
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What is this medicine?

TOSITUMOMAB (TOE sih too MOE mab) is a chemotherapy drug. This medicine allows radiation to target specific kinds of white blood cells. It is used to treat non-Hodgkin's lymphoma.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

-kidney disease
-low blood counts, like low white cell, platelet, or red cell counts
-thyroid disease
-an unusual or allergic reaction to tositumomab, other medicines, foods, dyes, or preservatives
-pregnant or trying to get pregnant
-breast-feeding

How should I use this medicine?

This medicine is for infusion into a vein. It is administered in a hospital or clinic by a specially trained health care professional.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

What if I miss a dose?

It is important not to miss a dose. Call your doctor or health care professional if you are unable to keep an appointment.

What may interact with this medicine?

  • medicines that treat or prevent blood clots like warfarin, enoxaparin, and dalteparin
  • vaccines

Talk to your doctor or health care professional before taking any of these over-the-counter medicines:

  • acetaminophen
  • aspirin
  • ibuprofen
  • ketoprofen
  • naproxen

What should I watch for while using this medicine?

Report any side effects that you notice during your treatment right away, such as changes in your breathing, fever, chills, dizziness or lightheadedness. These effects are more common with the first dose.

Visit your prescriber or health care professional for checks on your progress. You will need to have regular blood work. Report any other side effects. The side effects can continue after you finish your treatment. Continue your course of treatment even though you feel ill unless your doctor tells you to stop.

Call your doctor or health care professional for advice if you get a fever, chills or sore throat, or other symptoms of a cold or flu. Do not treat yourself. This drug decreases your body's ability to fight infections. Try to avoid being around people who are sick.

This medicine may increase your risk to bruise or bleed. Call your doctor or health care professional if you notice any unusual bleeding.

Be careful brushing and flossing your teeth or using a toothpick because you may get an infection or bleed more easily. If you have any dental work done, tell your dentist you are receiving this medicine.

Avoid taking products that contain aspirin, acetaminophen, ibuprofen, naproxen, or ketoprofen unless instructed by your doctor. These medicines may hide a fever.

Men and women must use effective birth control while taking this medicine and for 12 months after completing therapy. Do not become pregnant while taking this medicine. There is a potential for serious side effects to an unborn child. Talk to your health care professional or pharmacist for more information. Do not breast-feed an infant while taking this medicine.

After taking this medicine you will have radioactivity in your body for a period of time, usually for a week or two following the treatment. Your doctor or other health care provider will give you instructions about how to prevent exposing others to this radioactivity. Follow all instructions carefully.

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Last Updated: August 20, 2012
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