sertraline (generic name)

It is used to treat depression
(SER tra leen)
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What is this medicine?

SERTRALINE (SER tra leen) is used to treat depression. It may also be used to treat obsessive compulsive disorder, panic disorder, post-trauma stress, premenstrual dysphoric disorder (PMDD) or social anxiety.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
  • bipolar disorder or a family history of bipolar disorder
  • diabetes
  • heart disease
  • liver disease
  • receiving electroconvulsive therapy
  • seizures (convulsions)
  • suicidal thoughts, plans, or attempt by you or a family member
  • an unusual or allergic reaction to sertraline, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?

Take this medicine by mouth. Follow the directions on the prescription label.

Before taking your dose, you need to dilute the solution in a beverage. Measure your medicine dose using the dropper in the bottle. Next, place the measured dose in at least 4 ounces (one-half cup) of water, ginger-ale, lemon-lime soda, lemonade or orange juice and mix. Do not mix in grapefruit juice or in any other liquids other than those listed.

Drink all of mixed liquid immediately. Do not mix the dose and store it for later. It must be taken right away. You may take this medicine with or without food. Take your medicine at regular intervals. Do not take your medicine more often than directed. Do not stop taking this medicine suddenly except upon the advice of your doctor. Stopping this medicine too quickly may cause serious side effects or your condition may worsen.

A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time.

Talk to your pediatrician regarding the use of this medicine in children. While this drug may be prescribed for children as young as 7 years for selected conditions, precautions do apply.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

Do not take this medicine with any of the following medications:
  • disulfiram
  • linezolid
  • MAOIs like Carbex, Eldepryl, Marplan, Nardil, and Parnate
  • metronidazole
  • methylene blue (injected into a vein)
  • pimozide
  • thioridazine

This medicine may also interact with the following medications:

  • alcohol
  • aspirin and aspirin-like medicines
  • certain medicines for depression, anxiety, or psychotic disturbances
  • certain medicines for migraine headaches like almotriptan, eletriptan, frovatriptan, naratriptan, rizatriptan, sumatriptan, zolmitriptan
  • certain medicines for seizures like carbamazepine, valproic acid, phenytoin
  • cimetidine
  • digoxin
  • diuretics
  • fentanyl
  • furazolidone
  • isoniazid
  • lithium
  • medicines that treat or prevent blood clots like warfarin, enoxaparin, and dalteparin
  • medicines to control heart rhythm like flecainide or propafenone
  • medicines for sleep
  • NSAIDs, medicines for pain and inflammation, like ibuprofen or naproxen
  • procarbazine
  • rasagiline
  • supplements like St. John's wort, kava kava, valerian
  • tolbutamide
  • tramadol
  • tryptophan

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Last Updated: May 03, 2013
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