isoniazid-rifampin (generic name)

It is used to treat tuberculosis (TB)
(eye soe NYE a zid; RIF am pin)
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What is this medicine?

ISONIAZID; RIFAMPIN (eye soe NYE a zid; RIF am pin) is a combination of two antibiotics. It is used to treat tuberculosis (TB). It will not work for colds, flu, or other viral infections.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
  • diabetes
  • HIV positive
  • if you frequently drink alcohol-containing beverages
  • kidney disease
  • liver disease
  • malnutrition
  • tingling of the fingers or toes, or other nerve disorder
  • an unusual or allergic reaction to isoniazid, rifampin, rifabutin, other medicines, foods, dyes or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?

Take this medicine by mouth with a full glass of water. Follow the directions on the prescription label. Take this medicine on an empty stomach, either 1 hour before or 2 hours after food. Take your medicine at regular intervals. Do not take your medicine more often than directed. Take all of your medicine as directed even if you think you are better. Do not skip doses or stop your medicine early. Skipping doses may make the TB resistant to this medicine and other medicines. Do not stop taking except on your doctor's advice.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

Overdosage: If you think you've taken too much of this medicine contact a poison control center or emergency room at once.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

Do not take this medicine with any of the following medications:

-atomoxetine
-certain antiviral medicines for HIV or AIDS
-dronedarone
-green tea
-levodopa
-MAOIs like Carbex, Eldepryl, Marplan, Nardil, and Parnate
-procarbazine
-ranolazine
-sirolimus
-voriconazole
This medicine may also interact with the following medications:

-acetaminophen
-antacids
-atovaquone
-barbiturates like phenobarbital
-beta-blockers like metoprolol and propranolol
-calcium channel blockers like diltiazem, nifedipine and verapamil
-certain antibiotics like ciprofloxacin
-certain medicines for depression, anxiety, or psychotic disturbances
-certain medicines for diabetes, like glipizide or glyburide
-certain medicines for fungal infections like fluconazole, ketoconazole and itraconazole
-certain medicines for irregular heart beat like disopyramide, mexiletine, quinidine
-certain medicines for seizures like carbamazepine, phenobarbital, phenytoin, valproic acid
-certain medicines for sleep
-certain medicines that treat or prevent blood clots like warfarin
-chloramphenicol
-clarithromycin
-clofibrate
-cyclosporine
-dapsone
-diazepam
-digoxin
-doxycycline
-enalapril
-female hormones, like estrogens or progestins and birth control pills, patches, rings, or injections
-haloperidol
-levothyroxine
-methadone
-narcotic medicines for pain
-quinine
-sulfamethoxazole; trimethoprim
-steroid medicines like prednisone or cortisone
-tacrolimus
-theophylline

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Last Updated: May 31, 2011
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