imipramine (generic name)

Tofranil-PM (brand name)

It is used to treat depression
(im IP ra meen)
Table of Contents
powered by healthline

Average Ratings

What is this medicine?

IMIPRAMINE (im IP ra meen) is used to treat depression. This medicine can also help children who have a nighttime bed wetting problem.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
  • an alcohol problem
  • asthma, difficulty breathing
  • bipolar disorder or schizophrenia
  • difficulty passing urine, prostate trouble
  • fast or irregular heart beat
  • glaucoma
  • heart disease or recent heart attack
  • kidney or liver disease
  • seizures
  • stroke
  • thoughts or plans of suicide, a previous suicide attempt, or family history of suicide attempt
  • thyroid disease
  • an unusual or allergic reaction to imipramine, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Take your doses at regular intervals. Do not take your medicine more often than directed. Do not stop taking this medicine suddenly except upon the advice of your doctor. Stopping this medicine too quickly may cause serious side effects or your condition may worsen.

A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed. While this drug may be prescribed for children as young as 6 years for selected conditions, precautions do apply.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

Do not take this medicine with any of the following medications:
  • amoxapine
  • arsenic trioxide
  • certain medicines used to regulate abnormal heartbeat or to treat other heart conditions
  • cisapride
  • cocaine
  • grepafloxacin
  • halofantrine
  • levomethadyl
  • linezolid
  • MAOIs like Carbex, Eldepryl, Marplan, Nardil, and Parnate
  • methylene blue (injected into a vein)
  • other medicines for mental depression
  • phenothiazines like perphenazine, thioridazine and chlorpromazine
  • pimozide
  • procarbazine
  • sparfloxacin
  • St. John's Wort
  • ziprasidone

This medicine may also interact with the following medications:

  • atropine and related drugs like hyoscyamine, scopolamine, tolterodine and others
  • barbiturate medicines for inducing sleep or treating seizures like phenobarbital
  • cimetidine
  • clonidine
  • local anesthetics
  • medicines for high blood pressure
  • prescription pain medications
  • seizure or epilepsy medicine such as carbamazepine or phenytoin
  • stimulants like dexmethylphenidate or methylphenidate
  • thyroid hormones

Page: 1 2 Next >
Last Updated: May 06, 2013
Licensed from
Top of page
General Drug Tools
General Drug Tools view all tools
Tools for
Healthy Living
Tools for Healthy Living view all tools
Search Tools
Search Tools view all tools
Insurance Plan Tools
Insurance Plan Tools view all tools

What is a reference number?

When you register on this site, you are assigned a reference number. This number contains your profile information and helps UnitedHealthcare identify you when you come back to the site.

If you searched for a plan on this site in a previous session, you might already have a reference number. This number will contain any information you saved about plans and prescription drugs. To use that reference number, click on the "Change or view saved information" link below.

You can retrieve information from previous visits to this site, such as saved drug lists and Plan Selector information.