everolimus (generic name)

Afinitor is used to treat certain types of cancer
(eve ROE li mus)
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What is this medicine?

EVEROLIMUS (eve ROE li mus) decreases the activity of your immune system. Afinitor is used to treat certain types of cancer. Zortress is used for kidney and liver transplant rejection prophylaxis.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

-diabetes
-heart disease
-high cholesterol
-immune system problems
-infection (especially a virus infection such as chickenpox, cold sores, or herpes)
-kidney disease
-liver disease
-low blood counts, like low white cell, platelet, or red cell counts
-rare hereditary problems of galactose intolerance, the Lapp lactase deficiency, or glucose-galactose malabsorption
-an unusual or allergic reaction to everolimus, other medicines, foods, dyes, or preservatives
-pregnant or trying to get pregnant
-breast-feeding

How should I use this medicine?

Take this medicine by mouth with a full glass of water. Follow the directions on the prescription label. You can take this medicine with or without food, but always take Zortress the same way. Do not cut, crush, or chew this medicine. Do not take with grapefruit juice. Take your medicine at regular intervals. Do not take it more often than directed. Do not stop taking except on your doctor's advice.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

Overdosage: If you think you've taken too much of this medicine contact a poison control center or emergency room at once.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

This medicine may interact with the following medications:

-antiviral medicines for HIV or AIDS
-aprepitant
-carbamazepine
-certain medicines for cholesterol like simvastatin
-clarithromycin
-cyclosporine
-dexamethasone
-diltiazem
-erythromycin
-fluconazole
-grapefruit juice
-itraconazole
-ketoconazole
-live vaccines
-nefazodone
-nicardipine
-phenobarbital
-phenytoin
-rifabutin
-rifampin
-telithromycin
-verapamil
-voriconazole

What should I watch for while using this medicine?

Visit your doctor or health care professional for regular check-ups. You may need regular tests to monitor possible side effects of the drug.

This medicine may affect blood sugar levels. If you have diabetes, check with your doctor or health care professional before you change your diet or the dose of your diabetic medicine.

Women should inform their doctor if they wish to become pregnant or think they might be pregnant. There is a potential for serious side effects to an unborn child. Talk to your health care professional or pharmacist for more information. Do not breast-feed an infant while taking this medicine.

Afinitor may make you feel generally unwell. This is not uncommon, as chemotherapy can affect healthy cells as well as cancer cells. Report any side effects. Continue your course of treatment even though you feel ill unless your doctor tells you to stop.

Call your doctor or health care professional for advice if you get a fever, chills or sore throat, or other symptoms of a cold or flu. Do not treat yourself. This drug decreases your body's ability to fight infections. Try to avoid being around people who are sick.

This medicine may increase your risk to bruise or bleed. Call your doctor or health care professional if you notice any unusual bleeding.

Be careful brushing and flossing your teeth or using a toothpick because you may get an infection or bleed more easily. If you have any dental work done, tell your dentist you are receiving this medicine.

Avoid taking products that contain aspirin, acetaminophen, ibuprofen, naproxen, or ketoprofen unless instructed by your doctor. These medicines may hide a fever.

If you have had a kidney transplant, immediately tell your doctor if your incision site is red, warm, or painful. Also, tell your doctor if your incision site opens up or swells or if contains blood, fluid, or pus.

Keep out of the sun. If you cannot avoid being in the sun, wear protective clothing and use sunscreen. Do not use sun lamps or tanning beds/booths.

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Last Updated: February 19, 2013
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