conjugated estrogens topical (generic name)

Premarin (brand name)

This cream can help relieve symptoms associated with menopause
(CON ju gate ed ESS troe jenz)
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What is this medicine?

CONJUGATED ESTROGENS (CON ju gate ed ESS troe jenz) are a mixture of female hormones. This cream can help relieve symptoms associated with menopause.like vaginal dryness and irritation.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
  • abnormal vaginal bleeding
  • blood vessel disease or blood clots
  • breast, cervical, endometrial, or uterine cancer
  • dementia
  • diabetes
  • gallbladder disease
  • heart disease or recent heart attack
  • high blood pressure
  • high cholesterol
  • high level of calcium in the blood
  • hysterectomy
  • kidney disease
  • liver disease
  • migraine headaches
  • protein C deficiency
  • protein S deficiency
  • stroke
  • systemic lupus erythematosus (SLE)
  • tobacco smoker
  • an unusual or allergic reaction to estrogens other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?

This medicine is for use in the vagina only. Do not take by mouth. Follow the directions on the prescription label. Use at bedtime unless otherwise directed by your doctor or health care professional. Use the special applicator supplied with the cream. Wash hands before and after use. Fill the applicator with the cream and remove from the tube. Lie on your back, part and bend your knees. Insert the applicator into the vagina and push the plunger to expel the cream into the vagina. Wash the applicator with warm soapy water and rinse well. Use exactly as directed for the complete length of time prescribed. Do not stop using except on the advice of your doctor or health care professional.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

A patient package insert for the product will be given with each prescription and refill. Read this sheet carefully each time. The sheet may change frequently.

What if I miss a dose?

If you miss a dose, use it as soon as you can. If it is almost time for your next dose, use only that dose. Do not use double or extra doses.

What may interact with this medicine?

Do not take this medicine with any of the following medications:
  • aromatase inhibitors like aminoglutethimide, anastrozole, exemestane, letrozole, testolactone

This medicine may also interact with the following medications:

  • barbiturates used for inducing sleep or treating seizures
  • carbamazepine
  • grapefruit juice
  • medicines for fungal infections like itraconazole and ketoconazole
  • raloxifene or tamoxifen
  • rifabutin
  • rifampin
  • rifapentine
  • ritonavir
  • some antibiotics used to treat infections
  • St. John's Wort
  • warfarin

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Last Updated: March 21, 2012
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