codeine/phenylephrine/promethazine (generic name)

It helps to stop or reduce coughing and congestion of colds or allergies
(KOE deen; fen il EF rin; proe METH a zeen)
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What is this medicine?

CODEINE; PHENYLEPHRINE; PROMETHAZINE (KOE deen; fen il EF rin; proe METH a zeen) is a cough suppressant, a decongestant, and an antihistamine. It helps to stop or reduce coughing and congestion of colds or allergies. This medicine will not treat an infection.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
  • blood vessel disease
  • breathing problems like asthma or chronic obstructive pulmonary disease (COPD)
  • drug abuse or addiction
  • eczema
  • glaucoma
  • head injury
  • heart disease
  • lung or breathing disease, like asthma or chronic obstructive pulmonary disease (COPD)
  • other chronic illness
  • seizure disorder
  • sleep apnea
  • taken an MAOI like Carbex, Eldepryl, Marplan, Nardil, or Parnate in last 14 days
  • thyroid disease
  • trouble passing urine
  • an allergic or unusual reaction to codeine, phenylephrine, promethazine, phenothiazines, sulfites, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?

Take this medicine by mouth. Follow the directions on the prescription label. Use a specially marked spoon or container to measure each dose. Ask your pharmacist if you do not have one. Household spoons are not accurate. Take this medicine with food or milk if it upsets your stomach. Take your medicine at regular intervals. Do not take it more often than directed.

Talk to your pediatrician regarding the use of this medicine in children. While this drug may be prescribed for selected conditions, precautions do apply. This medicine is not approved for use in children less than 6 years old. Certain formulations of this medicine are also not approved for use in adolescents less than 16 years old.

Patients over 65 years old may have a stronger reaction to this medicine and need smaller doses.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take extra or double doses.

What may interact with this medicine?

Do not take this medicine with any of the following medications:
  • bromocriptine
  • disopyramide
  • ergot alkaloids like dihydroergotamine, ergonovine, ergotamine, methylergonovine
  • MAOIs like Carbex, Eldepryl, Marplan, Nardil, and Parnate
  • risperidone
  • stimulant medicines for attention disorders, weight loss, or to stay awake
  • thioridazine

This medicine may also interact with the following medications:

  • alcohol
  • antihistamines for allergy, cough and cold
  • atropine
  • barbiturate medicines for sleep or seizures
  • certain medicines for bladder problems like oxybutynin, tolterodine
  • certain medicines for Parkinson's disease like benztropine, trihexyphenidyl
  • certain medicines for stomach problems like dicyclomine, hyoscyamine
  • certain medicines for travel sickness like scopolamine
  • ipratropium
  • medicines for asthma or breathing problems
  • medicines for depression, anxiety, or psychotic disturbances
  • medicines for sleep
  • muscle relaxants
  • narcotic medicines (opiates) for pain
  • tramadol

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Last Updated: August 28, 2012
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