cisapride (generic name)

It is used to treat heartburn in patients with gastroesophageal reflux disease (GERD)
(SIS a pride)
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What is this medicine?

CISAPRIDE (SIS a pride) is used to treat heartburn in patients with gastroesophageal reflux disease (GERD). Because of the serious risks associated with this medicine it should only be used when lifestyle changes and other medicines have not worked. This medicine in only available from your doctor, who must register with the drug company and meet certain criteria for the use of this drug. This medicine has not been available in pharmacies since August 2000. For information, the manufacturer has provided the following toll-free number (877) 795-4247.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
  • eating disorder, like anorexia or bulimia
  • heart disease or heart failure
  • heart rhythm problems
  • heart valve problems
  • history of low levels of calcium, potassium, or magnesium
  • kidney disease
  • liver disease
  • lung disease
  • stomach bleeding, blockage, or ulceration
  • an unusual or allergic reaction to cisapride, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?

Take this medicine by mouth. Follow the directions on the prescription label. Shake well before using. Use a specially marked spoon or container to measure your medicine. Ask your pharmacist if you do not have one. Household spoons are not accurate. Take this medicine on an empty stomach, at least 15 minutes before eating and at bedtime. Do not take your medicine more often than directed.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

Do not take this medicine with any of the following medications:
  • alfuzosin
  • apomorphine
  • aprepitant
  • arsenic trioxide
  • certain antibiotics like ciprofloxacin, clarithromycin, dalfopristin;quinuprostin, erythromycin, gatifloxacin, gemifloxacin, levofloxacin, moxifloxacin, norfloxacin, ofloxacin, sparfloxacin, telithromycin or troleandomycin
  • certain medicines for cancer like daunorubicin and doxorubixin
  • chloroquine
  • cimetidine
  • clozapine
  • conivaptan
  • cyclobenzaprine
  • cyclosporine
  • danazol
  • diltiazem
  • dolasetron
  • droperidol
  • ethinyl estradiol
  • general and local anesthetics
  • grapefruit juice
  • halofantrine
  • haloperidol
  • hawthorn
  • imatinib
  • isoniazid
  • levomethadyl
  • medicines for fungal infections like fluconazole, itraconazole, ketoconazole, posaconazole, or voriconazole
  • medicines for treating HIV infection or AIDS
  • medicines for treating depression, psychosis, or other mental problems
  • medicines used to treat erectile dysfunction (ED) like sildenafil, tadalafil, and vardenafil
  • methadone
  • mifepristone
  • nicardipine
  • octreotide
  • palonosetron
  • pentamidine
  • phenothiazines like chlorpromazine, fluphenazine, mesoridazine, perphenazine, prochlorperazine, promethazine, thioridazine, trifluoperazine
  • pimozide
  • quinine
  • ranolazine
  • risperidone
  • sodium phosphates
  • some medicines for treating heart-rhythm problems like amiodarone, disopyramide, bretylium, dofetilide, flecainide, ibutilide, procainamide, propafenone, quinidine, sotalol
  • tacrolimus
  • verapamil
  • zafirlukast
  • zileuton
  • ziprasidone

This medicine may also interact with the following medications:

  • diuretics
  • insulin

What should I watch for while using this medicine?

Visit your doctor or health care professional for regular checks on your progress. For this medicine to work properly it is important to make lifestyle changes. Eat smaller meals, elevate the head of your bed 6 to 8 inches, avoid high-fat foods, chocolate, alcohol, smoking, caffeine and carbonated drinks.

If you have any fainting spells or rapid or irregular heartbeat, stop taking this drug immediately. Contact your health care professional right away for evaluation.

Do not drink grapefruit juice while you are taking this medicine. Grapefruit juice could increase your risk of having serious side effects from this medicine.

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Last Updated: March 30, 2009
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