chlorpheniramine/hydrocodone/PSE (generic name)

Hydrocof-HC (brand name)

It is used to treat the cough and congestion of colds and other respiratory infections
(klor fen IR a meen; hye droe KOE done; soo doe e FED rin)
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What is this medicine?

CHLORPHENIRAMINE; HYDROCODONE; PSEUDOEPHEDRINE (klor fen IR a meen; hye droe KOE done; soo doe e FED rin) is a combination of an antihistamine, cough suppressant, and a decongestant. It is used to treat the cough and congestion of colds and other respiratory infections. It is also used to treat the symptoms of allergy. This medicine will not treat an infection.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
  • asthma
  • diabetes
  • drug abuse or addiction
  • glaucoma
  • heart disease
  • high blood pressure
  • if you have taken an MAOI like Carbex, Eldepryl, Marplan, Nardil, or Parnate in last 14 days
  • recent head trauma
  • stomach ulcer
  • trouble passing urine
  • an unusual or allergic reaction to chlorpheniramine, codeine, hydrocodone, pseudoephedrine, other medicines, foods, dyes or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?

Take this medicine by mouth. Follow the directions on the prescription label. Shake well before using. Use a specially marked spoon or container to measure each dose. Ask your pharmacist if you do not have one. Household spoons are not accurate. Take your medicine at regular intervals. Do not take it more often than directed.

Talk to your pediatrician regarding the use of this medicine in children. While this drug may be prescribed for children as young as 6 years old for selected conditions, precautions do apply. This medicine is not approved for use in children less than 6 years old.

Patients over 60 years old may have a stronger reaction and need a smaller dose.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

Do not take this medicine with any of the following medications:
  • MAOIs like Carbex, Eldepryl, Marplan, Nardil, and Parnate

This medicine may also interact with the following medications:

  • alcohol
  • barbiturates like phenobarbital
  • certain heart medicines like metoprolol and digoxin
  • medicines for blood pressure
  • medicines for depression, anxiety, or psychotic disturbances
  • medicines for sleep
  • medicines for stomach problems like hyoscyamine
  • methyldopa
  • muscle relaxers
  • naltrexone
  • narcotic medicines for pain
  • other medicines for cold, cough, or allergy

What should I watch for while using this medicine?

Use exactly as directed by your doctor or health care professional. Do not take more than the recommended dose. You may develop tolerance to this medicine if you take it for a long time. Tolerance means that you will get less cough relief with time. Tell your doctor or health care professional if your symptoms do not improve or if they get worse.

If you have been taking this medicine for a long time, do not suddenly stop taking it because you may develop a severe reaction. Your body becomes used to the medicine. This does NOT mean you are addicted. Addiction is a behavior related to getting and using a drug for a nonmedical reason. If your doctor wants you to stop the medicine, the dose will be slowly lowered over time to avoid any side effects.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effect of this medicine. Avoid alcoholic drinks.

Your mouth may get dry. Chewing sugarless gum or sucking hard candy, and drinking plenty of water may help. Contact your doctor if the problem does not go away or is severe.

This medicine may cause dry eyes and blurred vision. If you wear contact lenses you may feel some discomfort. Lubricating drops may help. See your eye doctor if the problem does not go away or is severe.

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Last Updated: April 06, 2009
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