yohimbine (generic name)

an impotence agent - treats Erectile dysfunction, Sexual side effects of selective serotonin reuptake inhibitor, Dry mouth, Inhibition of plate...
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Tradition

WARNING: DISCLAIMER: The below uses are based on tradition, scientific theories, or limited research. They often have not been thoroughly tested in humans, and safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider. There may be other proposed uses that are not listed below.

Dosing

Adults (over 18 years old)

The following doses are based on human trials of pharmaceutical standardized yohimbine hydrochloride (available by prescription in the United States). No reliable clinical studies are available for administration of yohimbe bark extract. For erectile dysfunction (male impotence), 15 to 42 milligrams of yohimbine hydrochloride daily in three divided doses (for example, 5.4 to 10 milligrams three times daily) has been studied. For libido in women, 5.4 milligrams three times daily of yohimbine hydrochloride has been studied. For sexual side effects caused by antidepressant drugs, 2.7 to 16.2 milligrams of yohimbine hydrochloride has been studied. For autonomic dysfunction/orthostatic hypotension, 5.4 to 12 milligrams of daily yohimbine has been studied. For dry mouth (xerostomia), 6 milligrams three times daily of yohimbine hydrochloride has been studied.

Children (under 18 years old)

Yohimbe and yohimbine hydrochloride are not recommended for use in children.

Safety

DISCLAIMER: Many complementary techniques are practiced by healthcare professionals with formal training, in accordance with the standards of national organizations. However, this is not universally the case, and adverse effects are possible. Due to limited research, in some cases only limited safety information is available.

Allergies

In theory, allergy/hypersensitivity to yohimbe, any of its constituents, or yohimbine-containing products may occur.

Side Effects and Warnings

Yohimbe bark extract is traditionally said to cause occasional skin flushing, piloeretion (body hair standing up), painful urination, genital pain, reduced appetite, agitation, dizziness, headache, irritability, nervousness, tremors, or insomnia.

Multiple adverse effects have been associated with the use of the drug yohimbine hydrochloride, although in recommended doses, it is usually tolerated. If adverse effects occur, discontinuing the drug will likely stop the effects. In theory, these same side effects may also occur with the use of yohimbe bark extract, which contains variable (usually low) amounts of yohimbine.

There are reports of rash, flushing, breathing difficulty, cough, runny nose, nausea, vomiting, increased salivation, diarrhea, increased frequency of urination, kidney failure, muscle aches, and a lupus-like syndrome with the use of yohimbine hydrochloride. Yohimbine has also been associated with tremulousness, insomnia, anxiety, irritability, and excitability. Yohimbine may precipitate panic attacks, anxiety, manic episodes, or psychosis in patients with a history of mental illness.

In animal research, yohimbine has been associated with increased motor activity and seizures at higher doses. In humans, yohimbine may change the seizure threshold (the likelihood that a seizure will happen in some people) and may cause blood pressure/heart rate increases, fluid retention, chest discomfort, and heart rhythm abnormalities. Higher doses may lower blood pressure. Yohimbine can enter the brain through the bloodstream. Yohimbine may increase the risk of bleeding by altering platelet function and may dangerously reduce the number of white blood cells (agranulocytosis).

Symptoms of toxicity from yohimbine can include paralysis, dangerously low blood pressure, heart rhythm abnormalities, heart failure, and death. These same risks theoretically may also exist with yohimbe bark extract, depending on the concentration of yohimbine present and the amount ingested. Beta-blocker drugs such as metoprolol (Lopressor®, Toprol®) may be protective against yohimbine toxicity.

Pregnancy & Breastfeeding

Yohimbe should be avoided during pregnancy because it may relax the uterus and may be toxic to the fetus. Yohimbe should be avoided during breastfeeding, due to reports of deaths in children.

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