pyridoxine (generic name)
a vitamin b complex - treats Hyperkinetic cerebral dysfunction syndrome, Depression, Angioplasty, Pregnancy-induced nausea and vomiting, Immune...
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Interactions with Drugs
Preliminary research suggests that pyridoxine could exacerbate amiodarone (Cordarone®)-induced photosensitivity. Other research suggests a protective effect. Due to conflicting information, a firm conclusion cannot be drawn at this time but monitoring may be warranted.
Destruction of normal gastrointestinal flora by antibiotics can cause decreased production of the B vitamins. Clinical significance is unknown.
Cycloserine is an antibiotic that may cause anemia or peripheral neuritis by acting as a pyridoxine antagonist or increasing renal excretion of pyridoxine. Requirements for pyridoxine may be increased in patients receiving cycloserine.
Use of estrogens and estrogen-containing oral contraceptives can interfere with pyridoxine metabolism, reducing serum pyridoxine levels. The need for pyridoxine supplementation has not been adequately studied.
Hydralazine (Apresoline®) can increase pyridoxine requirements. The need for pyridoxine supplementation has not been adequately studied.
Pyridoxine enhances the metabolism of levodopa (Sinemet®), reducing its anti-parkinsonism effects. Carbidopa and levodopa used together may avoid this interaction.
Penicillamine (Cuprimine®, Depen®) can increase pyridoxine requirements.
Preliminary data suggests that pyridoxine can reduce plasma levels of phenobarbital (Luminal®), possibly by increasing metabolism. Patients taking phenobarbital should avoid high doses of pyridoxine.
Preliminary data suggests that pyridoxine can reduce plasma levels of phenytoin (Dilantin®), possibly by increasing metabolism. Patients taking phenytoin should avoid high doses of pyridoxine.
Theophylline (Theo-Dur®), a medication used for asthma, interferes with pyridoxine metabolism. Study results of supplemental pyridoxine in these patients are inconclusive.
Interactions with Herbs and Dietary Supplements
Theoretically, herbs and supplements with estrogen-like activity may interact with pyridoxine. The need for pyridoxine supplementation has not been adequately studied.
This information is based on a professional level monograph edited and peer-reviewed by contributors to the Natural Standard Research Collaboration (www.naturalstandard.com): Ethan M. Basch, MD (Memorial Sloan-Kettering Cancer Center); Dawn Costa, BA, BS (Natural Standard Research Collaboration); Cynthia Dacey, PharmD (Northeastern University); Jenna Hollenstein (Natural Standard Research Collaboration); Shaina Tanguay-Colucci, BS (Natural Standard Research Collaboration); Catherine Ulbricht, PharmD (Massachusetts General Hospital); Christine Ulbricht, BS (University of Massachusetts); Mamta Vora, PharmD (Northeastern University); Wendy Weissner, BA (Natural Standard Research Collaboration).
BibliographyDISCLAIMER: Natural Standard developed the above evidence-based information based on a thorough systematic review of the available scientific articles. For comprehensive information about alternative and complementary therapies on the professional level, go to www.naturalstandard.com. Selected references are listed below.
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Sahakian V, Rouse D, Sipes S, Rose N, et al. Vitamin B6 is effective therapy for nausea and vomiting of pregnancy: a randomized, double-blind placebo-controlled study. Obstet Gynecol 1991;78(1):33-36.
Schnyder G, Roffi M, Flammer Y, et al. Effect of homocysteine-lowering therapy with folic acid, vitamin B12, and vitamin B6 on clinical outcome after percutaneous coronary intervention: the Swiss Heart study: a randomized controlled trial. JAMA 8-28-2002;288(8):973-979.
Thaver D, Saeed MA, Bhutta ZA. Pyridoxine (vitamin B6) supplementation in pregnancy. Cochrane Database Syst Rev 2006 Apr 19;(2):CD000179.
Woodside JV, Yarnell JW, McMaster D, et al. Effect of B-group vitamins and antioxidant vitamins on hyperhomocysteinemia: a double-blind, randomized, factorial-design, controlled trial. Am J Clin Nutr 1998;67(5):858-866.
Wyatt KM, Dimmock PW, Jones PW, et al. Efficacy of vitamin B-6 in the treatment of premenstrual syndrome: systematic review. BMJ 5-22-1999;318(7195):1375-1381.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.