Lentinula edodes (generic name)

treats Immunomodulator, HIV, Cancer, and Genital warts
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Interactions

Interactions with Drugs

Although not well studied in humans, lentinan and shiitake extracts may interact with antifungals, antivirals, antioxidants, and immunomodulators. Caution is advised.

Lentinan has been used as an adjunct with cancer therapies to prolong survival time and increase quality of life.

Based on preliminary animal study, shiitake may reduce blood levels of free cholesterol, triglycerides, and phospholipids.

In a laboratory study, essential oil from shiitake inhibited platelet aggregation and therefore may increase the risk of bleeding when taken with drugs that also increase bleeding risk like warfarin (Coumadin®) or ibuprofen (Advil, Aleve®). Lentinan, the polysaccharide derivative of shiitake, may cause mildly abnormal blood cell counts (thrombocytopenia).

Lentinus edodes has been shown to inhibit cyclooxygenase activity in laboratory study and therefore may interact with drugs like Tylenol® or Celebrex®.

Mushroom polysaccharides, especially beta-glucans such as lentinan from Lentinus edodes, may interfere with the way the liver breaks down certain drugs (through the suppression of CYP1As). Consult a qualified healthcare professional, including a pharmacist, to check for interactions.

Taking didanosine (ddI, Videx®), the nucleoside reverse transcriptase inhibitor (NRTI) antiretroviral drug for HIV, with lentinan (the polysaccharide derivative of shiitake) may help to increase CD4 levels in HIV positive patients.

Lentinan may cause increased sun sensitivity that can be worsened by drugs like Retin-A® and tetracycline antibiotics.

Interactions with Herbs and Dietary Supplements

Although not well studied in humans, lentinan and shiitake extracts may interact with antifungals, antivirals, antioxidants, and immunomodulators. Caution is advised.

Based on preliminary animal study, shiitake may reduce blood levels of free cholesterol, triglycerides, and phospholipids.

In a laboratory study, essential oil from shiitake inhibited platelet aggregation and therefore may increase the risk of bleeding when taken with herbs or supplements that also increase bleeding risk like garlic or saw palmetto. Lentinan, the polysaccharide derivative of shiitake, may cause mildly abnormal blood cell counts (thrombocytopenia).

Mushroom polysaccharides, especially beta-glucans such as lentinan from Lentinus edodes, may interfere with the way the liver breaks down certain herbs and supplements (through suppression of CYP1As). Please check with a doctor and pharmacist to screen for potential interactions.

Lentinan may cause increased sun sensitivity that can be worsened by herbs and supplements like St. John's wort, or capsaicin.

Attribution

This information is based on a systematic review of scientific literature, and was peer-reviewed and edited by contributors to the Natural Standard Research Collaboration (www.naturalstandard.com): Julie Conquer, PhD (RGB Consulting); Dawn Costa, BA, BS (Natural Standard Research Collaboration); Edzard Ernst, MD, PhD, FRCP (Peninsula Medical School); Nicole Giese, MS (Natural Standard Research Collaboration); Dana A. Hackman, BS (Northeastern University); Julie Montalbano, PharmD (Massachusetts College of Pharmacy); Carolyn Williams Orlando, MA (Natural Standard Research Collaboration); Lisa Scully, PharmD (Massachusetts College of Pharmacy); Isabell Syelsky, PharmD (Northeastern University); Shaina Tanguay-Colucci, BS (Natural Standard Research Collaboration); Catherine Ulbricht, PharmD (Massachusetts General Hospital); Wendy Weissner, BA (Natural Standard Research Collaboration); Shannon Welch, PharmD (Northeastern University); Denise Wong, PharmD (Northeastern University).

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