shark cartilage (generic name)

an herbal product - treats Macular degeneration, Psoriasis, Arthritis, Pain, and Cancer
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Herbs & Supplements

Synonyms

AE-941, Arthrovas™, cartilage, Cephaloscyllium ventriosum, chondroitin sulfate, chondrosine, Haifischknorpel (German), Houtsmuller diet, Mustelus californicus, Neoretna, Neovastat®, octasaccharides, polar shark cartilage, Psovascar™, shark, shark fin soup, smooth-hound shark, Sphyrna lewini (hammerhead shark), squalamine, Squalus acanthias (spiny dogfish shark), swell shark, U-955.

Note: The product Catrix® is made from cow cartilage, not from shark cartilage.

Background

Shark cartilage is one of the most popular supplements in the United States, with over 40 brand name products sold in 1995 alone. Primarily used for cancer, its use became popular in the 1980s after several poor-quality studies reported "miracle" cancer cures.

Laboratory research and animal studies of shark cartilage or the shark cartilage derivative product AE-941 (Neovastat®) have demonstrated some anti-cancer (anti-angiogenic) and anti-inflammatory properties. However, there is currently not enough reliable human evidence to recommend for or against shark cartilage for any condition. There are several ongoing cancer studies. Many trials are supported by manufacturers of shark cartilage products, which raises questions about impartiality.

Commercial shark cartilage is primarily composed of chondroitin sulfate (a type of glycosaminoglycan), which is further broken down in the body into glucosamine and other end products. Although chondroitin and glucosamine have been extensively studied for osteoarthritis, there is a lack of evidence supporting the use of unprocessed shark cartilage preparations for this condition. Shark cartilage also contains calcium. Manufacturers sometimes promote its use for calcium supplementation.

Shark cartilage supplements at common doses can cost as much as $700-1,000 per month.

Evidence

DISCLAIMER: These uses have been tested in humans or animals. Safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider.

Arthritis: Chondroitin sulfate, a component of shark cartilage, has been shown to benefit patients with osteoarthritis. However, the concentrations of chondroitin in shark cartilage products may be too small to be helpful. The ability of shark cartilage to block new blood vessel growth or reduce inflammation is proposed to be helpful in rheumatoid arthritis. However, there is limited research in these areas, and more studies are needed before a strong recommendation can be made.
Grade: C

Cancer: For several decades, shark cartilage has been proposed as a cancer treatment. Studies have shown shark cartilage or the shark cartilage product AE-941 (Neovastat®) to block the growth of new blood vessels, a process called "anti-angiogenesis," which is believed to play a role in controlling the growth of some tumors. There have also been several reports of successful treatments of end-stage cancer patients with shark cartilage, but these have not been well designed or included reliable comparisons to accepted treatments. Many studies have been supported by shark cartilage product manufacturers, which may influence the results. In the United States, shark cartilage products cannot claim to cure cancer, and the U.S. Food and Drug Administration (FDA) has sent warning letters to companies not to promote products in this way. Without further evidence from well-designed human trials, it remains unclear if shark cartilage is of any benefit in cancer and patients are advised to check with their doctor and pharmacist before taking shark cartilage.
Grade: C

Macular degeneration: It is proposed that shark cartilage or the shark cartilage product AE-941 (Neovastat®) may be helpful in patients with macular degeneration. A small amount of research suggests possible benefits, but more study is needed before a recommendation can be made.
Grade: C

Pain: Based on laboratory studies, shark cartilage may reduce inflammation. However, it is unclear if shark cartilage is a safe or helpful treatment for pain in humans.
Grade: C

Psoriasis: Shark cartilage products have been tested by mouth or on the skin in people with psoriasis. However, no clear benefits have been shown. More research is needed before a conclusion can be drawn.
Grade: C

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