Safflower (generic name)

treats Atherosclerosis, Diabetes mellitus type 2, Cardiovascular disorders, Total parenteral nutrition, Toxicity, Familial hyperlipidemia, Kidn...
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Interactions with Drugs

In children with cystic fibrosis, ingestion of safflower oil, antacids, cimetidine and pancreatic capsules had greater increases in plasma linoleic acid levels.

Safflower may increase the risk of bleeding. Caution is advised in patients with bleeding disorders or taking drugs that may increase the risk of bleeding. Some examples include, aspirin, anticoagulants ("blood thinners") such as warfarin (Coumadin®) or heparin, anti-platelet drugs such as clopidogrel (Plavix®), and non-steroidal anti-inflammatory drugs (NSAIDS) such ibuprofen (Motrin®, Advil®) or naproxen (Naprosyn®, Aleve®). Dosing adjustments may be necessary.

Safflower may prohibit platelet aggregation and anticoagulation, and may promote microcirculation. Caution is advised when taking safflower with calcium channel blockers (verapamil). However, results are conflicting since safflower oil has also been documented to cause hypercoagulation. Check with a qualified healthcare professional before combining therapies.

Ingestion of safflower oil may decrease serum total cholesterol, HDL, LDL, apolipoprotein B, and malondialdehyde-LDL. Results are conflicting, although caution is advised nonetheless in patients taking cholesterol-lowering agents in combination with safflower oil.

Safflower oil may alter blood sugar levels; however, clinical relevance is unclear. Caution is advised when using medications that may lower blood sugar. Patients taking drugs for diabetes by mouth or insulin should be monitored closely by a qualified healthcare professional, including a pharmacist. Medication adjustments may be necessary.

Safflower oil may cause a modest fall in blood pressure and interact additively with hypotensive (blood pressure lowering) agents. However, several other clinical studies have shown no effect on blood pressure.

Safflower oil may have immunostimulation properties. Although clinical relevance is unknown, caution is advised when combining immunostimulating agents and safflower oil.

Although not well studied in humans, safflower oil may remit the symptoms of low-dose lithium neurotoxicity. This appears to be a positive interaction, although more study is needed to clarify this finding.

Safflower oil may increase pentobarbital-associated mortalities.

Kinobeon A, a rose-colored pigment found in safflower tissue, demonstrated potent tyrosinase activity. Caution is advised when taking safflower oil with tyrosinase inhibitors.

Interactions with Herbs and Dietary Supplements

In children with cystic fibrosis, ingestion of safflower oil, antacids, cimetidine and pancreatic capsules had greater increases in plasma linoleic acid levels. In theory, safflower oil may interact with herbs or supplements with antacid effects.

Safflower may increase the risk of bleeding. Caution is advised in patients with bleeding disorders or taking herbs or supplements that are believed to increase the risk of bleeding.

Safflower oil may interact additively with fish oil to reduce C-reactive protein and interleukin-6. However, results are unclear. Caution is advised when combining fish oil with safflower oil.

Ingestion of safflower oil may decrease serum total cholesterol, HDL, LDL, apolipoprotein B, and malondialdehyde-LDL. Results are conflicting, although caution is advised nonetheless in patients taking cholesterol-lowering agents, such as red yeast rice, in combination with safflower oil.

Safflower oil may alter blood sugar levels. Caution is advised when using herbs or supplements that may lower blood sugar. Blood glucose levels may require monitoring, and doses may need adjustment.

Safflower oil may cause a modest fall in blood pressure and interact additively with hypotensive (blood pressure lowering) agents. However, several other clinical studies have shown no effect on blood pressure.

Safflower may interact when taken with safflower-containing products, such as Renal Disease Basic-prescription (RDBP) and EH0202 (pumpkin seed extract, safflower seed extract, Asian plantain seed extract, and Japanese honeysuckle flower extract). Safflower oil may also interact with calcium.

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