Saccharomyces boulardii (generic name)

treats Crohn's disease, Diarrhea, Diarrhea in children, Irritable bowel syndrome, Nutritional support, and Antibacterial
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Interactions

Interactions with Drugs

Concomitant antibiotic treatment may change gastrointestinal flora, subsequently increasing steady state levels of Saccharomyces boulardii in humans. According to various clinical trials, use of Saccharomyces boulardii in combination with antibiotics decreases the frequency and duration of diarrhea. Caution is also advised when taking Saccharomyces boulardii with other antidiarrheal agents due to additive effects.

Use of antifungal agents may result in decreased efficacy of Saccharomyces boulardii.

Use of metronidazole plus iodoquinol plus Saccharomyces boulardii was more effective than metronidazole plus iodoquinol alone for reducing diarrhea associated with amebiasis (intestinal infection). Similarly, use of mesalamine plus Saccharomyces boulardii may be more effective than mesalamine alone for reducing diarrhea associated with Crohn's disease. These may be examples of positive interactions.

Saccharomyces boulardii taken in combination with monoamine oxidase inhibitors (MAOIs) may lower blood pressure.

Interactions with Herbs and Dietary Supplements

Concomitant antibiotic treatment with herbs or supplements may change gastrointestinal flora, subsequently increasing steady state levels of Saccharomyces boulardii in humans. According to various clinical trials, use of Saccharomyces boulardii in combination with antibiotics decreases the frequency and duration of diarrhea.

Caution is also advised when taking Saccharomyces boulardii with other antidiarrheal herbs or supplements due to additive effects.

Use of antifungal herbs or supplements may result in decreased efficacy of Saccharomyces boulardii.

Saccharomyces boulardii taken in combination with herbs or supplements with monoamine oxidase inhibitor-like activity may lower blood pressure.

Attribution

This information is based on a systematic review of scientific literature, and was peer-reviewed and edited by contributors to the Natural Standard Research Collaboration (www.naturalstandard.com): Ethan Basch, MD (Memorial Sloan-Kettering Cancer Center); Julie Conquer, PhD (RGB Consulting); Elizabeth Copeland, MD (Boston Medical Center); Molly Davis, PharmD (University of Rhode Island); Bonnie Diamond (Harvard Medical School); Nicole Giese, MS (Natural Standard Research Collaboration); Sooyoun Kang, PharmD (Massachusetts College of Pharmacy); Shaina Tanguay-Colucci, BS (Natural Standard Research Collaboration); Catherine Ulbricht, PharmD (Massachusetts General Hospital); Mamta Vora, PharmD (Northeastern University); Wendy Weissner, BA (Natural Standard Research Collaboration).

Bibliography

DISCLAIMER: Natural Standard developed the above evidence-based information based on a thorough systematic review of the available scientific articles. For comprehensive information about alternative and complementary therapies on the professional level, go to www.naturalstandard.com. Selected references are listed below.

Akil I, Yilmaz O, Kurutepe S, et al. Influence of oral intake of Saccharomyces boulardii on Escherichia coli in enteric flora. Pediatr Nephrol. 2006;21(6):807-810.

Bleichner G, Blehaut H, Mentec H, et al. Saccharomyces boulardii prevents diarrhea in critically ill tube-fed patients. A multicenter, randomized, double-blind placebo-controlled trial. Intensive Care Med 1997;23(5):517-523.

Can M, Besirbellioglu BA, Avci IY, et al. Prophylactic Saccharomyces boulardii in the prevention of antibiotic-associated diarrhea: a prospective study. Med Sci Monit. 2006;12(4):I19-I22.

Chouraqui JP, Dietsch J, Musial C, et al. Saccharomyces boulardii (SB) in the management of toddler diarrhea: a double-blind-placebo controlled study [abstract]. J Pediatr Gastroenterol Nutr 1995;20(4):463.

Dalmasso G, Loubat A, Dahan S, et al. Saccharomyces boulardii prevents TNF-alpha-induced apoptosis in EHEC-infected T84 cells. Res Microbiol 2006;157(5):456-465.

De Preter V, Vanhoutte T, Huys G, et al. Effect of lactulose and Saccharomyces boulardii administration on the colonic urea-nitrogen metabolism and the bifidobacteria concentration in healthy human subjects. Aliment.Pharmacol Ther 4-1-2006;23(7):963-974.

Facchinetti F, Nappi RE, Sances MG, et al. Effects of a yeast-based dietary supplementation on premenstrual syndrome. A double-blind placebo-controlled study. Gynecol Obstet Invest 1997;43(2):120-124.

Geyik MF, Aldemir M, Hosoglu S, et al. The effects of Saccharomyces boulardii on bacterial translocation in rats with obstructive jaundice. Ann R.Coll Surg Engl. 2006;88(2):176-180.

Kollaritsch H, Holst H, Grobara P, et al. [Prevention of traveler's diarrhea with Saccharomyces boulardii. Results of a placebo controlled double-blind study]. Fortschr.Med 3-30-1993;111(9):152-156.

Kotowska M, Albrecht P, Szajewska H. Saccharomyces boulardii in the prevention of antibiotic-associated diarrhoea in children: a randomized double-blind placebo-controlled trial. Aliment.Pharmacol.Ther. 3-1-2005;21(5):583-590.

McFarland LV. Meta-analysis of probiotics for the prevention of antibiotic associated diarrhea and the treatment of Clostridium difficile disease. Am J Gastroenterol. 2006;101(4):812-822.

McFarland LV, Surawicz CM, Greenberg RN, et al. A randomized placebo-controlled trial of Saccharomyces boulardii in combination with standard antibiotics for Clostridium difficile disease. JAMA 6-22-1994;271(24):1913-1918.

Potts L, Lewis SJ, Barry R. Randomised double blind placebo controlled study of the ability of Saccharomyces boulardii to prevent antibiotic related diarrhoea. Gut 1996;38 (suppl 1):A61.

Sougioultzis S, Simeonidis S, Bhaskar KR, et al. Saccharomyces boulardii produces a soluble anti-inflammatory factor that inhibits NF-kappaB-mediated IL-8 gene expression. Biochem Biophys.Res Commun. 4-28-2006;343(1):69-76.

Szajewska H, Ruszczynski M, Radzikowski A. Probiotics in the prevention of antibiotic-associated diarrhea in children: a meta-analysis of randomized controlled trials. J Pediatr 2006;149(3):367-372.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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