Rosemary (generic name)

treats Alopecia areata and Anxiety/stress
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Interactions

Interactions with Drugs

Rosemary may increase the risk of bleeding when taken with drugs that increase the risk of bleeding. Some examples include aspirin, anticoagulants ("blood thinners") such as warfarin (Coumadin®) or heparin, anti-platelet drugs such as clopidogrel (Plavix®), and non-steroidal anti-inflammatory drugs such as ibuprofen (Motrin®, Advil®) or naproxen (Naprosyn®, Aleve®).

Water extracts of rosemary may inhibit angiotensin I-converting enzyme (ACE). This may cause low blood pressure. Caution is advised in patients taking medications that also can reduce blood pressure, such as ACE inhibitors.

Rosemary may have anti-inflammatory, antispasmodic, antifungal, and antibacterial activity. Patients taking any medications with similar effects should use rosemary cautiously.

Rosemary and its various constituents have been noted for their high antioxidant properties, including carnosol, carnosic acid, rosmanol, epirosmanol, and hesperidin.

Alcohol extracts of rosemary may have antitumorigenic activity. Rosemary may increase the accumulation of commonly used chemotherapeutic agents, including doxorubicin and vinblastine, in cancer cells that express P-glycoprotein. However, rosemary extract probably does not affect accumulation or efflux of doxorubicin in cells that lack P-glycoprotein. Use cautiously in patients taking agents for cancer or chemotherapy drugs.

Constituents in rosemary extract may inhibit cholesterol oxidation product formation. Caution is advised in patients taking cholesterol-lowering medications.

Rosemary may interfere with the way the body processes certain drugs using the liver's "cytochrome P450" enzyme system. As a result, the levels of these drugs may be decreased in the blood, and reduce the intended effects. Patients taking any medications should check the package insert and speak with a qualified healthcare professional, including a pharmacist, about possible interactions.

Rosemary has been shown to increase the effects of furosemide (Lasix®), which belongs to the class of loop diuretics. Patients taking medications that increase the flow of urine should consult with a qualified healthcare professional, including a pharmacist, before combining therapies.

Rosemary may precipitate lithium toxicity due to its diuretic properties. Caution is advised in patients with bipolar disorder or those taking medications containing lithium. Medication adjustments may be necessary.

Rosemary extract may increase blood sugar levels in both diabetics and non-diabetics. Caution is advised when using medications that may lower blood sugar. Patients taking drugs for diabetes by mouth or insulin should be monitored closely by a qualified healthcare provider. Medication adjustments may be necessary.

In theory, rosemary, rosemary essential oil, and its components may inhibit bone resorption. Theoretically, there may be additive effects. Patients taking medications for osteoporosis should consult with a qualified healthcare professional, including a pharmacist.

Although not well-studied, rosemary may also interact with peptic ulcer disease drugs, and estrogen-containing medications such as birth control pills.

Interactions with Herbs & Dietary Supplements

Rosemary may increase the risk of bleeding when taken with herbs and supplements that are believed to increase the risk of bleeding. Multiple cases of bleeding have been reported with the use of Ginkgo biloba, and fewer cases with garlic and saw palmetto. Numerous other agents may theoretically increase the risk of bleeding, although this has not been proven in most cases.

Water extracts of rosemary may inhibit angiotensin I-converting enzyme (ACE). This may cause low blood pressure. Caution is advised in patients taking herbs or supplements that also can reduce blood pressure.

Rosemary may have antispasmodic, antifungal, antibacterial, and anti-inflammatory effects. Patients taking any herbs or supplements with similar effects should use rosemary cautiously.

Rosemary and its various constituents have been noted for their high antioxidant properties, including carnosol, carnosic acid, rosmanol, epirosmanol, and hesperidin. Combination with lycopene may increase rosemary's antioxidative effects. Consult with a qualified healthcare professional, including a pharmacist, before making decisions about therapies.

Alcohol extracts of rosemary may have antitumorigenic activity. Use caution in patients taking herbs or supplements that may be used for cancer, due to possible additive effects.

Constituents in rosemary extract may inhibit cholesterol oxidation product formation. Caution is advised in patients taking cholesterol-lowering herbs and supplements, such as red yeast rice.

Rosemary may interfere with the way the body processes certain herbs or supplements using the liver's "cytochrome P450" enzyme system. As a result, the levels of other herbs or supplements may become too low in the blood. It may also alter the effects that other herbs or supplements potentially may have on the P450 system.

Rosemary may enhance the effects of herbal agents used to increase the flow of urine.

Although not well studied, rosemary may enhance the liver's rate of deactivating estrogen in the body. Caution is advised when combining rosemary with other herbs and supplements that contain phytoestrogens.

Rosemary extract may increase blood sugar levels in both diabetics and non-diabetics. Caution is advised when using agents that may lower blood sugar. Patients taking herbs or supplements for diabetes by mouth or insulin should be monitored closely by a qualified healthcare provider. Medication adjustments may be necessary.

Rosemary may decrease iron absorption. Caution is advised in patients taking iron supplements or multivitamins.

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