Reishi mushroom (generic name)

treats Proteinuria, Rheumatoid arthritis, Diabetes mellitus type 2, High blood pressure, Poisoning, Pain, Chronic hepatitis B, Cancer, and Coro...
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Interactions

Interactions with Drugs

Reishi mushrooms are likely unsafe in patients with hemophilia due to its high adenosine content.

Reports have suggested that reishi may antagonize the effects of amphetamines.

Reishi therapy may increase or decrease the activity of certain antibiotics such as ampicillin, cefazolin, oxytetracycline, and chloramphenical.

A study conducted on the antiherpetic activity of the acidic protein bound polysaccharide (APBP) that was isolated from capophores of Ganoderma lucidum had synergistic effects when administered with the prescription antiviral drug acyclovir.

Reishi and anticoagulants or NSAIDs may theoretically lead to additive effects or an increased risk of bleeding. Reishi may cause bleeding due to prolongation of prothrombin time. Ganoderma lucidum inhibits platelet aggregation.

Ganoderma lucidum may cause additive blood pressure-lowering effects.

Based on animal study, Ganoderma lucidum may cause an additive blood sugar-lowering effect.

Reishi with HMG-CoA reductase inhibitor drugs ("statins") may result in additive effects.

Theoretically, the use of reishi and protease inhibitors may result in additive effects.

The risk of liver damage may increase when reishi mushroom powder is taken with drugs that are known to damage the liver.

Interactions with Herbs and Dietary Supplements

Reishi and anticoagulant herbs and supplements may theoretically lead to additive effects, increasing bleeding risk.

Ganoderma lucidum may cause additive blood pressure-lowering effects with herbs and supplements such as fish oil, coenzyme Q10, and ginseng.

Ganoderma lucidum may cause additive blood sugar-lowering effects with herbs and supplements such as beta-glucan, bitter melon, ginseng, gymnema, and chromium.

Theoretically, reishi may result in additive effects when taken with herbs and supplements like guggul, red rice yeast, or garlic.

The risk of liver damage may increase when reishi mushroom powder is taken with herbs or supplements that are known to damage the liver.

Attribution

This information is based on a systematic review of scientific literature, and was peer-reviewed and edited by contributors to the Natural Standard Research Collaboration (www.naturalstandard.com): Tracee Rae Abrams, PharmD (University of Rhode Island); Stephen Bent, MD (University of California, San Francisco); Heather Boon, BScPhm, PhD (University of Toronto); Dawn Costa, BA, BS (Natural Standard Research Collaboration); Cynthia Dacey, PharmD (Natural Standard Research Collaboration); Nicole Giese, MS (Natural Standard Research Collaboration); Dana A. Hackman, BS (Northeastern University); Lisa Scully, PharmD (Massachusetts College of Pharmacy); Erica Seamon, PharmD (Nova Southeastern University); Shaina Tanguay-Colucci, BS (Natural Standard Research Collaboration); Catherine Ulbricht, PharmD (Massachusetts General Hospital); Nazhiyath Vijarian, MD (Natural Standard Research Collaboration); Wendy Weissner, BA (Natural Standard Research Collaboration); Shannon Welch, PharmD (Northeastern University); Denise Wong, PharmD (Northeastern University); Jen Woods, BS (Natural Standard Research Collaboration); Kui Xu, PhD (Northeastern University).

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