Red Clover (generic name)

treats Prostate cancer, Cardiovascular - blood flow, High cholesterol, Menopausal symptoms, Prostate enlargement, Osteoporosis, Hormone replace...
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Interactions

Interactions with Drugs

Red clover may interfere with the way the liver processes some drugs using an enzyme called cytochrome P450 3A4. As a result, the levels of these drugs may be increased in the blood, and may cause increased effects or potentially serious adverse reactions. Patients using any medications should check the package insert and speak with a healthcare professional or pharmacist about possible interactions.

In theory, red clover may increase the risk of bleeding when taken with drugs that increase the risk of bleeding. Some examples include aspirin, anticoagulants ("blood thinners") such as warfarin (Coumadin®) or heparin, anti-platelet drugs such as clopidogrel (Plavix®), and non-steroidal anti-inflammatory drugs such as ibuprofen (Motrin®, Advil®) or naproxen (Naprosyn®, Aleve®). Because red clover contains estrogen-like chemicals, the effects of drugs with estrogen or estrogen-like properties may be altered, such as birth control pills or hormone replacement therapies like Premarin® and Provera®.

Red clover has been studied for lowering blood sugar with inconclusive results. Caution is warranted with diabetes or if taking other medications that may alter blood sugar until further research is available.

In theory, red clover may interact with other estrogen-containing medications. Red clover contains phytoestrogens, which are plant-based chemicals that are similar to estrogen and may act in the body like estrogen or may actually block the effects of estrogen.

Interactions with Herbs & Dietary Supplements

Red clover may interfere with the way the liver processes some drugs using an enzyme called cytochrome P450 3A4. As a result, red clover may cause the levels of other herbs or supplements to be too high in the blood. It may also alter the effects that other herbs or supplements possibly have on the P450 system.

In theory, red clover may increase the risk of bleeding when taken with herbs or supplements that increase the risk of bleeding. Multiple cases of bleeding have been reported with the use of Ginkgo biloba and fewer cases with garlic and saw palmetto. Numerous other agents may theoretically increase the risk of bleeding, although this has not been proven in most cases.

Because red clover contains estrogen-like chemicals, the effects of other agents believed to have estrogen-like properties may be altered.

Red clover has been studied for lowering blood sugar with inconclusive results. Caution is warranted with diabetes or if taking other herbs or supplements that may alter blood sugar until further research is available.

Attribution

This information is based on a systematic review of scientific literature, and was peer-reviewed and edited by contributors to the Natural Standard Research Collaboration (www.naturalstandard.com): Ernie-Paul Barrette, MD (Case Western Reserve School of Medicine); Ethan Basch, MD (Memorial Sloan-Kettering Cancer Center); Samuel Basch, MD (Mt. Sinai Medical Center, NY); Steve Bent, MD (University of California, San Francisco); Edzard Ernst, MD, PhD (University of Exeter); Sadaf Hashmi, MD, MPH (Natural Standard Research Group); Jenna Hollenstein, MS, RD (Natural Standard Research Collaboration); Jamie Nelsen, PharmD (University of Rhode Island); Adrianne Rogers, MD (Boston University School of Medicine); David Sollars MAc, HMC (New England School of Acupuncture); Philippe Szapary, MD, MPH (University of Pennsylvania); Shaina Tanguay-Colucci, BS (Natural Standard Research Collaboration); Candy Tsourounis, PharmD (University of California, San Francisco); Catherine Ulbricht, PharmD (Massachusetts General Hospital); Wendy Weissner, BA (Natural Standard Research Collaboration).

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