peppermint (generic name)
- Auto Immune Conditions
- Bladder & Kidney Health
- Brain & Nervous System
- Care Transitions
- Dental Health
- Emotional Health
- Eye Health
- Falls Prevention
- Financial Planning
- General Safety
- Health Care Basics
- Healthy Living
- Hearing Loss
- Heart Health
- High Blood Pressure
- Life Transitions
- Lung Health
- Men's Health
- Nutrition & Weight Management
- Pain Management
- Preventive Health
- Sexual Health
- Stomach & Digestive Health
- Stress & Anxiety
- Women's Health
Interactions with Drugs
Peppermint oil by mouth may increase blood levels of the drugs felodipine (Plendil®) and simvastatin (Zocor®). Peppermint oil increases levels of cyclosporine in the blood. Peppermint oil used on the skin with 5-fluorouracil (5-FU) may increase the rate of absorption of 5-FU.
Peppermint oil may interfere with the way the body processes certain drugs using the liver's "cytochrome P450" enzyme system. As a result, the levels of these drugs may be increased in the blood and may cause increased effects or potentially serious adverse reactions. Patients using these medications should check the package insert and speak with a qualified healthcare provider including a pharmacist about possible interactions.
Interactions with Herbs and Supplements
Peppermint oil may interfere with the way the body processes certain herbs or supplements using the liver's "cytochrome P450" enzyme system. As a result, the levels of other herbs or supplements may be too high in the blood. It may also alter the effects that other herbs or supplements possibly have on the P450 system. Patients using these medications should check the package insert and speak with a qualified healthcare provider including a pharmacist about possible interactions.
Peppermint may also interact with herbs and supplements that raise or lower blood pressure or have antacid properties. Caution is advised.
This information is based on a professional level monograph edited and peer-reviewed by contributors to the Natural Standard Research Collaboration (www.naturalstandard.com): Tracee Rae Abrams, PharmD (University of Rhode Island); Ethan Basch, MD (Memorial Sloan-Kettering Cancer Center); Dawn Costa, BA, BS (Natural Standard Research Collaboration); Nicole Giese, MS (Natural Standard Research Collaboration); Mary Giles, PharmD (University of Rhode Island); David Keifer, MD (University of Arizona); Catherine DeFranco Kirkwood, MPH, CCCJS-MAC (MD Anderson Cancer Center); Michelle Miranda, PharmD (University of Rhode Island); Adrianne Rogers, MD (Harvard Medical School); Shaina Tanguay-Colucci, BS (Natural Standard Research Collaboration); Catherine Ulbricht (Massachusetts General Hospital); Wendy Weissner, BA (Natural Standard Research Collaboration); Jen Woods, BS (Northeastern University).
BibliographyDISCLAIMER: Natural Standard developed the above evidence-based information based on a thorough systematic review of the available scientific articles. For comprehensive information about alternative and complementary therapies on the professional level, go to www.naturalstandard.com. Selected references are listed below.
Behrends M, Beiderlinden M, Peters J. Acute lung injury after peppermint oil injection. Anesth Analg 2005;101(4):1160-1162.
Cappello G, Spezzaferro M, Grossi L, et al. Peppermint oil (Mintoil) in the treatment of irritable bowel syndrome: a prospective double blind placebo-controlled randomized trial. Dig Liver Dis 2007 Jun;39(6):530-6.
Hiki N, Kurosaka H, Tatsutomi Y, et al. Peppermint oil reduces gastric spasm during upper endoscopy: a randomized, double-blind, double-dummy controlled trial. Gastrointest Endosc 2003;57(4):475-482.
Hur MH, Park J, Maddock-Jennings W et al. Reduction of mouth malodour and volatile sulphur compounds in intensive care patients using an essential oil mouthwash. Phytother Res 2007 Jul;21(7):641-3.
Inamori M, Akiyama T, Akimoto K, et al. Early effects of peppermint oil on gastric emptying: a crossover study using a continuous real-time 13C breath test (BreathID system). J Gastroenterol 2007 Jul;42(7):539-42. Epub 2007 Jul 25.
Kalavala M, Hughes TM, Goodwin RG, et al. Allergic contact dermatitis to peppermint foot spray. Contact Dermatitis. 2007 Jul;57(1):57-8.
Kline RM, Kline JJ, Di Palma J, et al. Enteric-coated, pH-dependent peppermint oil capsules for the treatment of irritable bowel syndrome in children. J Pediatr 2001;138(1):125-128.
Liu JH, Chen GH, Yeh HZ, et al. Enteric-coated peppermint-oil capsules in the treatment of irritable bowel syndrome: a prospective, randomized trial. J Gastroenterol 1997;32(6):765-768.
Madisch A, Heydenreich CJ, Wieland V, et al. Treatment of functional dyspepsia with a fixed peppermint oil and caraway oil combination preparation as compared to cisapride. A multicenter, reference-controlled double-blind equivalence study. Arzneimittelforschung 1999;49(11):925-932.
Melli MS, Rashidi MR, Nokhoodchi A, et al. A randomized trial of peppermint gel, lanolin ointment, and placebo gel to prevent nipple crack in primiparous breastfeeding women. Med Sci Monit 2007 Sep;13(9):CR406-411.
Pittler MH, Ernst E. Peppermint oil for irritable bowel syndrome: a critical review and meta-analysis. Am J Gastroenterol 1998;93(7):1131-1135.
Shin BC, Lee MS. Effects of aromatherapy acupressure on hemiplegic shoulder pain and motor power in stroke patients: a pilot study. J Altern Complement Med 2007 Mar;13(2):247-51.
Shkurupii VA, Kazarinova NV, Ogirenko AP, et al. [Efficiency of the use of peppermint (Mentha piperita L) essential oil inhalations in the combined multi-drug therapy for pulmonary tuberculosis]. Probl Tuberk 2002;(4):36-9.
Tate S. Peppermint oil: a treatment for postoperative nausea. J Adv Nurs 1997;26(3):543-549.
Veal L. The potential effectiveness of essential oils as a treatment for headlice. Pediculus humanus capitis. Complement Ther Nurs Midwifery 1996;2(4):97-101.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.