pantothenic acid (generic name)
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Interactions with Drugs
It has been noted that dexpanthenol may increase bleeding time and therefore potentially increase the risk of bleeding when combined with other agents with similar properties. However, there is limited evidence in this area, and this is generally not regarded as a serious potential risk.
In theory, pantothenic acid and dexpanthenol may increase the effects of cholinesterase inhibitor drugs (including multiple Alzheimer's drugs) by increasing production of acetylcholine, leading to potentially dangerous side effects. Examples of cholinesterase inhibitors include: donepezil (Aricept®), rivastigmine (Exelon®), galantamine (Reminyl®), tacrine (Cognex®), neostigmine (Prostigmin®), edrophonium chloride (Tensilon®), and pyridostigmine bromide (approved by the U.S. Food and Drug Administration (FDA) for use after exposure to the nerve gas Soman). Combining these agents should be avoided unless under strict medical supervision.
Drugs containing estrogen and progestin may increase the daily requirement of pantothenic acid.
Interactions with Herbs and Dietary Supplements
High doses of pantothenic acid may inhibit the absorption of biotin produced by microflora in the large intestine.
It has been noted anecdotally that dexpanthenol may increase bleeding time and therefore potentially may increase the risk of bleeding when combined with other agents with similar properties. However, there is limited evidence in this area and this is generally not regarded as a serious potential risk. Multiple cases of bleeding have been reported with the use of Ginkgo biloba, and fewer cases with garlic and saw palmetto. Numerous other agents may theoretically increase the risk of bleeding, although this has not been proven in most cases.
Estrogen and progestin may increase the body's daily requirement for pantothenic acid.
This information is based on a professional level monograph edited and peer-reviewed by contributors to the Natural Standard Research Collaboration (www.naturalstandard.com): Ethan Basch, MD (Memorial Sloan-Kettering Cancer Center); Dawn Costa, BA, BS (Natural Standard Research Collaboration); Shaina Tanguay-Colucci, BS (Natural Standard Research Collaboration); Catherine Ulbricht, PharmD (Massachusetts General Hospital); Christine Ulbricht, PharmD (University of Massachusetts); Wendy Weissner, BA (Natural Standard Research Collaboration).
BibliographyDISCLAIMER: Natural Standard developed the above evidence-based information based on a thorough systematic review of the available scientific articles. For comprehensive information about alternative and complementary therapies on the professional level, go to www.naturalstandard.com. Selected references are listed below.
Brenner A. The effects of megadoses of selected B complex vitamins on children with hyperkinesis: controlled studies with long-term follow-up. J Learn Disabil 1982;15:258-64.
Food and Nutrition Board, Institute of Medicine. Pantothenic acid. Dietary Reference Intakes: Thiamin, Riboflavin, Niacin, Vitamin B-6, Vitamin B-12, Pantothenic Acid, Biotin, and Choline. Washington, D.C.: National Academy Press; 1998:357-373.
Haslam RH, Dalby JT, Rademaker AW. Effects of megavitamin therapy on children with attention deficit disorders. Pediatrics 1984;74:103-1.
Lewis CM, King JC. Effect of oral contraceptives agents on thiamin, riboflavin, and pantothenic acid status in young women. Am J Clin Nutr 1980;33(4):832-838.
Loftus EV Jr, Tremaine WJ, Nelson RA, et al. Dexpanthenol enemas in ulcerative colitis: a pilot study. Mayo Clin Proc 1997 Jul;72(7):616-20.
Lokkevik E, Skovlund E, Reitan JB, et al. Skin treatment with bepanthen cream versus no cream during radiotherapy-a randomized, controlled trial. Acta Onco 1996;35:1021-6.
McCurdy PR. Is there an anemia responsive to pantothenic acid? J Am Geriatr Soc 1973;21(2):88-91.
Nice C, Reeves AG, Brinck-Johnsen T, et al. The effects of pantothenic acid on human exercise capacity. J Sports Med Phys Fitness 1984;24(1):26-29.
Srinivasan V, Belavady B. Nutritional status of pantothenic acid in Indian pregnant and nursing women. Int J Vitam Nutr Res 1976;46(4):433-438.
Verse T, Klocker N, Riedel F, et al. [Dexpanthenol nasal spray in comparison to dexpanthenol nasal ointment. A prospective, randomised, open, cross-over study to compare nasal mucociliary clearance] HNO 2004 Jul;52(7):611-5.
Walsh JH, Wyse BW, Hansen RG. Pantothenic acid content of 75 processed and cooked foods. J Am Diet Assoc 1981;78(2):140-144.
Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.