methylsulfonylmethane (generic name)

a nutraceutical product - treats Osteoarthritis and Allergic rhinitis
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DISCLAIMER: Many complementary techniques are practiced by healthcare professionals with formal training, in accordance with the standards of national organizations. However, this is not universally the case, and adverse effects are possible. Due to limited research, in some cases only limited safety information is available.


Avoid in individuals with a known allergy or hypersensitivity to MSM.

Side Effects and Warnings

Studies have shown safety and tolerability of MSM products when taken by mouth in recommended doses. Minimal side effects, including mild gastrointestinal discomfort, have been associated with the use of MSM. No studies on the long-term effects of MSM have been conducted.

Pregnancy and Breastfeeding

MSM is not recommended in pregnant or breastfeeding women due to a lack of available scientific evidence.


Interactions with Drugs

Although not well studied in humans, MSM may have anti-inflammatory and antioxidant activity. In theory, use of MSM with other anti-inflammatory or antioxidant agents may have additive effects.

Interactions with Herbs and Dietary Supplements

Although not well studied in humans, MSM may have anti-inflammatory and antioxidant activity. In theory, use of MSM with other anti-inflammatory or antioxidant herbs or supplements may have additive effects.


This information is based on a systematic review of scientific literature, and was peer-reviewed and edited by contributors to the Natural Standard Research Collaboration ( Tracee Abrams, PharmD (University of Rhode Island); Ethan Basch, MD (Natural Standard Research Collaboration); Nicole Giese, MS (Natural Standard Research Collaboration); Mary Giles, PharmD (Rhode Island University); Karta Purkh Singh Khalsa, CDN, RH (University of Texas); Adrianne Rogers, MD (Harvard Medical School); Erica Seamon, PharmD (Nova Southeastern University); Shaina Tanguay-Colucci, BS (Natural Standard Research Collaboration); Catherine Ulbricht, PharmD (Massachusetts General Hospital); Wendy Weissner, BA (Natural Standard Research Collaboration); Jennifer Woods, BS (Natural Standard Research Collaboration).


DISCLAIMER: Natural Standard developed the above evidence-based information based on a thorough systematic review of the available scientific articles. For comprehensive information about alternative and complementary therapies on the professional level, go to Selected references are listed below.

Barrager E, Veltmann JR Jr, Schauss AG, et al. A multicentered, open-label trial on the safety and efficacy of methylsulfonylmethane in the treatment of seasonal allergic rhinitis. J.Altern.Complement Med. 2002;8(2):167-173.

Beilke MA, Collins-Lech C, Sohnle PG. Effects of dimethyl sulfoxide on the oxidative function of human neutrophils. J Lab Clin Med 1987;110(1):91-96.

Horvath K, Noker PE, Somfai-Relle S, et al. Toxicity of methylsulfonylmethane in rats. Food Chem Toxicol 2002;40(10):1459-1462.

Layman DL, Jacob SW. The absorption, metabolism and excretion of dimethyl sulfoxide by rhesus monkeys. Life Sci 12-23-1985;37(25):2431-2437.

Lin A, Nguy CH, Shic F, et al. Accumulation of methylsulfonylmethane in the human brain: identification by multinuclear magnetic resonance spectroscopy. Toxicol.Lett. 9-15-2001;123(2-3):169-177.

Richmond VL. Incorporation of methylsulfonylmethane sulfur into guinea pig serum proteins. Life Sci 7-21-1986;39(3):263-268.

Usha PR, Naidu MU. Randomised, double-blind, parallel, placebo-controlled study of oral glucosamine, methylsulfonylmethane and their combination in osteoarthritis. Clin Drug Invest 2004;24:353-363.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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